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b细胞淋巴瘤诊疗规_范 课件
两组治疗的耐受性均良好,虽然R+CVP组的粒细胞减少略增加,但感染的发生率无差异,也未发生与治疗有关的死亡 美罗华显著提高了缓解率,延长了无病生存时间 德国低度淋巴瘤研究组( GLSG )牵头的随机临床,从2000年5月起, 超过800位初治的滤泡和套细胞淋巴瘤患者入组这个随机试验,疗程根据缓解出现的早或晚从6至8个,缓解患者再根据年龄二次分组分别接受移植或不同剂量干扰素维持治疗 总缓解率美罗华联合CHOP从90%提高到96%, 有显著差异. 2008年公布的GLSG2000的5年随访结果 Rituximab in Combination with CHOP in Patients with Follicular Lymphoma: Analysis of Treatment Outcome of 552 Patients Treated in a Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG) after a Follow up of 58 Months Sunday, December 7, 2008 Hall A (Moscone Center) Poster Board II-693 Christian Buske, Dr1*, Eva Hoster1*, Martin Dreyling1, Roswitha Forstpointner1*, Michael Kneba, MD, PhD2*, Norbert Schmitz3*, Rudolf Schmits4*, Bernd Metzner5, Marcel Reiser6*, Eva Lengfelder7*, Bernhard J Woermann8, Harriet Harder9*, Susanna Hegewisch-Becker10*, Wolfgang E. Berdel11, Georg Hess12*, Hartmut Eimermacher13*, Ali Aldaoud14*, Manfred Planker15*, Michael Unterhalt1* and Wolfgang Hiddemann, MD1 1Department of Internal Medicine III, University of Munich-Hopsital Gro?hadern, Munich, Germany22nd Department of Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany3Depatment of Hematology Stem cell transplantation, Asclepios Clinic St. Georg, Hamburg, Germany4H?matologie / Onkologie, Universit?tsklinik Homburg, Homburg / Saar, Germany5Klinikum Oldenburg, Oldenburg, Germany6Klinikum, Universit?t zu K?ln, K?ln, Germany7Dept. of Hematology/Oncology, University of Heidelberg, Mannheim, Germany8Dept. of Hematology/Oncology, Stadtische Kliniken Braunschweig, Braunschweig, Germany9Department of Hematology, Oncology and Tumor Immunology, Robert-R?ssle-Klinik at the HELIOS Clinic Berlin-Buch, Charitè, Berlin, Germany10Department of Oncology, Klinikum Eppendorf, University of Hamburg, Hamburg, Germany11Department of Medicine, Hematology and Oncology, University of Münster, Münster, Germany12Johannes Gutenberg-Universit?t, Mainz, Germany13Dept. of Hematology/ Oncology, St. Marien Hospital, Hagen, Ge
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