Body Buffer system - Biomedical engineering 体缓冲系统生物医学工程.pptVIP

In a metabolic alkalosis compensation by (no fully but relativly compensate). Slightly hypoventilation results in an elevation of PCO2, whilst in a respiratory alkalosis the kidneys increase HCO3- excretion, thereby lowering plasma [HCO3-]. --The PH is a fully compensated in acidosis. 2-bicarbonate generation A very important mechanism for correcting acidosis, in which the levels of CO2 or [HCO3-] affecting the carbonate dehydratase reaction in tubular cells reflect those in the extracellular fluid, there is a net loss of H+ (fig) Acid_Base disorders -Disturbances of H+ homoeostasis always involve the bicarbonate buffer pair. -In respiratory disturbances abnormalities of CO2 are primary. -Whereas so-called metabolic or non respiratory disturbances [HCO3-] is affected early and changes in CO2 are secondary. -Acid blood PH is known as acidaemia, and alkaline blood PH is called alkalaemia. -Abnormal processes, either respiratory or metabolic, generate abnormal amounts of acid or base,acidosis or alkalosis respectively. -The blood PH may or may not be abnormal because of the compensatory mechanisms Acidosis Acidosis occurs if there is a fall in the ratio [HCO3-]:PCO2in the extracellular fluid. It may be due to; 1-metabolic(non-respiratory) acidosis. In which the primary abnormality in the bicarbonate buffer system is a reduction in [HCO3-] 2-respiratory acidosis, In which the primary abnormality in the bicarbonate buffer system is rise in PCO2 The primary disorder in the bicarbonate buffer system in a metabolic acidosis is a reduction in [HCO3-],resulting in a fall in blood PH. The reduction in the HCO3- may be due to; Metabolic acidosis 1-its use in buffering H+ more rapidly than it can be generated by normal homeostatic mechanism 2-loss in the urine or gastrointestinal tract more rapidly than it can be generated by normal homeostatic mechanism. 3-impaired production . Some causes of metabolic a