Perinatal Hepatitis B Prevention ProgramTX Department of：围产期乙型肝炎预防programtx部.pptVIP

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Perinatal Hepatitis B Prevention ProgramTX Department of：围产期乙型肝炎预防programtx部.ppt

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Perinatal Hepatitis B Prevention ProgramTX Department of：围产期乙型肝炎预防programtx部

* * * One of the most studied vaccines and one of the safest. * * * 05/11/2010 Infants (%) with Chronic Hepatitis B Virus Infection by Treatment Group and Age Beasley RP. Dev Biol Stand 1982;54:363-375 HBIG Prophylaxis for Infants Born to HBeAg-positive Women HBIG temporarily protected infants from hepatitis B virus infection More infected infants developed active response (immunity) to HBV infection than chronic infection Reduced chronic infections by ~50%-75% before age 15 months New infections continued 05/11/2010 Beasley RP. Dev Biol Stand 1982;54:363-375 Hepatitis B Vaccine Trials Infants Born to HBsAg-Positive Women Vaccine efficacy defined as percent protected against chronic HBV infection in first year of life Historical controls for rates chronic infection, ~70%, 90% Rates of seroprotection (anti-HBsAg ≥10 mIU/ml) after 3 doses, measured at age 9-12 months; geometric mean titers anti-HBsAg Reviewed in: Mast E. Vaccine, Eds. Orenstein W, Plotkin S, 2004, 2009 05/11/2010 Hepatitis B Vaccine Trials Infants Born to HBeAg-Positive Women Plasma and recombinant vaccines Dosages 2.5 - 20 μg HBsAg protein Regimens First dose 24 hours (3-5 days) of life Many schedules: 0, 1, 6 months; 0,1,2,12 months; 0, 1.5, 9 months, etc) With/without HBIG 24 hours after birth Reviewed in: Mast E. Vaccine, Eds. Orenstein W, Plotkin S, 2004, 2009 05/11/2010 Recombinant Hepatitis B Vaccine Efficacy Infants Born to HBeAg-Positive Women Country HBIG Hepatitis B Vaccine Efficacy Without and With HBIG Ages 0, 1, 6 months Other Dosages Schedules Burma Thailand No MSD 5 ug 93% 86%-89% 59%-79% Thailand GSK 10 ug 92% 95% Thailand USA Yes MSD 5 ug 89% 92% 88%-97% Thailand Taiwan GSK 10 ug 100% 90% 89%-98% 05/11/2010 Pongpipat D. 1989; Stevens CE. 1975, 1979;1985,1992. Lee C-Y. 1991, 997; Poovorawan Y. 1989; 997; 2009; Lolekha S. 2002; Mast E. Va