醋酸曲普瑞治疗特发性中枢性早熟临床效果观察.docVIP

醋酸曲普瑞林治疗特发性中枢性早熟临床效果观察 　　【摘要】目的：探讨注射用醋酸曲普瑞林用于特发性中枢性早熟的治疗效果及安全性。方法：选取84例符合诊断标准且于我院进行治疗的特发性中枢性早熟患儿纳入研究，且采用随机、单盲法将其分作两组，对照组42例患儿给予醋酸甲地孕酮片，观察组42例患儿同时给予醋酸曲普瑞林，均连续治疗6个月，对其生长指标、性激素水平及不良反应情况进行比较。结果：两组患儿治疗前身高、体重、生长速度、预测身高及BA/CA比较差异均无统计学意义（P?0.05）；而治疗后观察组患儿上述各项指标分别为（131.86±8.46）cm、（26.83±3.84）kg、（2.33±0.42）cm/半年、（161.89±2.99）cm和（1.15±0.29），与本组治疗前和对照组治疗后进行比较差异均具有统计学意义（P中国论文网 /6/viewhtm　　【关键词】醋酸曲普瑞林；特发性中枢性早熟；治疗效果 　　【Abstract】Objectives： To investigate the curative effect and safety of injection of triptorelin acetate in treatment of idiopathic central precocious puberty. Methods： 84 children with idiopathic central precocious puberty in our hospital were included in the study and divided into two groups randomly. According to the single blind method， 42 cases in the control group were given megestrol acetate tablets， while 42 cases in the observation group were given triptorelin acetate in the meantime， for continuous treatment of 6 months. The growth index， sex hormone levels and adverse reaction of the two groups were compared. Results： The body weight， height growth rate， predicted height and BA/CA of the two groups before treatment were not significant difference （P0.05）； and after the treatment， the above indexes in the observation group were （131.86±8.46） cm， （26.83±3.84） kg， （2.33±0.42） cm/half year， （161.89± 2.99） cm and （1.15 + 0.29）. Compared with these before the treatment and the indexes of control groups after treatment， the differences were significant （P0.05）. The above indexes in the observation group after treatment were （1.89±0.43） IU/L， （2.34 ±0.34） IU/L， （11.29±3.02） pg/mL. Compared with the indexes of the observation group before treatment and the indexes of control group after treatment， the differences were statistically significant （P 　　【中图分类号】R167【文献标志码】A 　　随着近些年生活水平的不断提高和生活方式的逐渐转变，儿童特发性中枢性早熟（ICPP）的发生率也逐年增加，成为儿童内分泌科临床上的常见疾病，且女童中的发生率显著高于男童，威胁其身心健康[1，2]。ICPP患儿主要表现为青春期前出现第二性征，因患儿下丘脑-垂体-性腺功能过早启动而致，目前临床主要采用促性腺激素释放激素类似物治疗，疗效显著，已被临床所广泛认可[3，4]。我院于20