2011原发性骨质疏松症诊治指南张红ppt课件.pptVIP

骨 质 疏 松 的 治 疗 * 抗骨吸收药物－雌激素类 雌激素治疗骨质疏松 对BMD有益 预防椎体骨折，可能也预防非椎体骨折 绝经早期效果更好(60岁) HRT Component of the WHI:Summary of Results at 5.2 Years (EarlyTermination) *Nominal statistical significance at the 0.05 level. The Writing Group for the Women’s Health Initiative Investigators. JAMA. 2002;288(3):321–333. In postmenopausal women with an intact uterus, HRT was associated with: 15% increase in global index (risks exceeded benefits)* 29% increase in CHD events* 41% increase in stroke* 111% increase in VTE静脉血栓 disease* 22% increase in total cardiovascular disease* 26% increase in invasive breast cancer