磁敏感加权成像测量脑铁沉积在帕金森病中的临床应用.docVIP

磁敏感加权成像测量脑铁沉积在帕金森病中的临床应用 　　[摘要] 目的 通过磁敏感加权成像技术（SWI）定量研究帕金森病（PD）脑铁沉积，探讨其临床应用价值。 方法 收集2010年6月～2016年6月于内蒙古医科大学附属医院神经内科诊治的40例帕金森病患者为PD组，另选同期健康志愿者20例为对照组（NC组）。所有PD患者进行HoehnYahr分级，分期≤1.5为早期组（PD1组）23例，分期1.5为中晚期（PD2组）组17例。采用3.0TMR系统对各组中脑核团行常规MRI平扫和SWI序列扫描，分别测量各核团位相值，并对测量结果进行比较和相关性分析。 结果 PD组与NC组双侧尾状核（CN）、苍白球（GP）、双侧壳核（PU）、红核（RN）、黑质（SN）相位值比较均有所增加，提示有较多的铁沉积。PD1组、PD2组与NC组中SN、GP和RN的相位值比较，差异有统计学意义（P 0.05）；PD2组SN、GP、CN相位值与NC组比较，差异有统计学意义（P 0.05）。 结论 SWI可反映脑内铁沉积，可以通过测量相关脑核团信号强度并计算出相位值以评价脑铁沉积，为PD患者的辅助诊断与治疗提供一定帮助。 　　[关键词] 磁敏感加权成像；帕金森病；铁沉积 　　[中图分类号] 742.5 [文献标识码] A [文章编号] 1673-7210（2017）10（a）-0117-04 　　[Abstract] Objective To clinical value of iron deposition in brain of Parkinson disease （PD） by susceptibility weighted imaging （SWI）. Methods From June 2010 to June 2016， in Department of Neurology， Affiliated Hospital of Inner Mongolia Medical University， 40 PD patients were selected as PD group， 20 healthy volunteers were enrolled into the control group （NC group） at the same time. All PD patients were graded by HoehnYahr， stage≤1.5 as early phase group （PD1 group） 23 cases， stage 1.5 as middle and advanced phase （PD2 group） 17 cases. brain nuclei of each group were examinated by MRI and SWI with 3.0TMR system， and the results were compared and analyzed. Results The phase values of caudate nucleus （CN）， globus pallidus （GP）， putamen （PU）， red nucleus （RN） and substantia nigra （SN） of patients in PD group increased compared with NC group， which indicated there was more iron deposits. The phase values of SN， GP and RN in PD1 group， PD2 group and NC group were compared， the differences were statistically significant （P 0.05）； the phase values of SN， GP， CN in PD2 group were compared with NC group， the differences were statistically significant （P 0.05）. Conclusion SWI can reflect the iron deposition in the brain， and it can be used to evaluate the brain iron deposition by measuring the signal intensity of related brain nuclei and calculating the phase value. It can provide some