某地区烧伤科非发酵菌阴性杆菌感染情况及耐药性分析.docVIP

某地区烧伤科非发酵菌阴性杆菌感染情况及耐药性分析 　　【摘要】目的:了解笔者医院烧伤科近几年非发酵阴性杆菌分布特点及药物敏感情况，为烧伤科合理选用抗生素、控制医院感染提供实验室依据。方法:回顾性分析2007年5月至2010年5月笔者医院烧伤科培养结果分离为非发酵菌阴性杆菌住院患者的临床资料。结果 3年共分离非发酵阴性杆菌812株，以铜绿假单胞菌(50.00%)和鲍曼不动杆菌(19.33%)为主，药敏结果显示，铜绿假单胞菌对头孢哌酮/舒巴坦、阿米卡星、亚胺培南耐药率分别为7.6%、8.9%、13.9%；而鲍曼不动杆菌对头孢哌酮/舒巴坦、阿米卡星、亚胺培南耐药率分别为8.3%、11.4%、23.5%。结论 非发酵阴性杆菌耐药性增加，多重耐药菌株不断增加，与滥用、长时间使用抗生素有关，建议临床根据药敏结果合理选用抗生素。 　　【关键词】烧伤感染；非发酵阴性杆菌；耐药性 　　Burn unit in an area of non-fermentative bacteria-negative bacilli and drug resistance of infection 　　LIU You-hong??1 JIANG Zhang-jia??1 YANG lei??1 SHEN hui??1 ZHANG gang??1 　　【Abstract】 Objective To Hospital burn unit in recent years, the author of non-negative bacteria fermentation and drug sensitivity distribution case, for the rational use of antibiotics in burn unit, hospital infection control to provide laboratory evidence. Methods A retrospective study from May 2007 to May 2010 author hospital burn unit for non-fermenting bacteria culture results negative bacilli isolated patient clinical data. Results 3-year negative bacilli were isolated from 812 non-fermentative, Pseudomonas aeruginosa (50.00%) and Acinetobacter baumannii (19.33%), with drug susceptibility results showed that Pseudomonas aeruginosa to cefoperazone / sulbactam, amikacin, imipenem resistance rates were 7.6%, 8.9%, 13.9%; and Acinetobacter baumannii cefoperazone / sulbactam, amikacin, imine training Southern resistance rates were 8.3%, 11.4%, 23.5%. Conclusion The non-negative bacilli resistant to increased fermentation, multi-drug resistant strains increase, and abuse, prolonged use of antibiotics resistance, suggest that clinical use of antibiotics based on susceptibility results are reasonable. 　　【Key words】burn infection; non-negative bacteria fermentation; drug resistance 　　【中图分类号】R157 【文献标识码】B 【文章编号】1005-0515(2011)05-0022-01 　　 　　烧伤患者是发生医院感染的高危人群，由于住院时间长，皮肤黏膜屏障的破坏、广泛的创面形成、机体免疫能力的降低及侵入操作的使用使烧伤患者对病原菌易感性增加[1]，致使感染发生率远高于其他患者。烧伤感染一直是烧伤防治的重点, 是引起烧伤患者死亡的主要原因之一[2]。烧伤科细菌变化及耐药性改变与抗菌药物的应用密切相关,并直接影响大面积烧伤患者