妊娠晚期孕妇生殖道B族链球菌感染率调查及阴道微生物对感染影响.docVIP

妊娠晚期孕妇生殖道B族链球菌感染率调查及阴道微生物对感染影响 　　[摘 要] 目的：了解本地?^妊娠晚期妇女生殖道B族链球菌（GBS）的感染率，并探讨部分阴道微生物对妊娠晚期孕妇GBS感染影响。方法：选择2014年12月至2015年12月1228例妊娠35～37周孕妇及600例妊娠20～24周孕妇，取阴道下1/3分泌物及肛周分泌物，采用荧光定量聚合酶链反应（PCR）检测GBS；同时，分析孕妇阴道分泌物中微生物检出情况对GBS检出阳性率的影响。结果：孕晚期妇女生殖道GBS总检出率5.29%（65/1228），孕中期总检出率4.67%（28/600），组间差异无统计学意义（P0.05） 。孕晚期中25～29岁组妊娠妇女检出率最高（ 6.9%），但与其他各年龄组比较差异均无统计学意义（P0.05） 。孕妇阴道分泌物其他病原体的检出率依次为真菌、细菌和滴虫。真菌和细菌阳性组孕妇GBS检出率高于对应阴性组孕妇（P0.05）。阴道清洁度Ⅲ～Ⅳ度的孕妇GBS检出率为6.79%（33/486）高于清洁度Ⅰ～Ⅱ度的孕妇4.31%（32/742），但差异无统计学意义（P0.05）。结论：GBS 感染与不良妊娠结局具有相关性，对阴道真菌或细菌性阴道病检测阳性的孕妇应进行重点筛查。 　　[关键词] 链球菌，无乳；妊娠末期；聚合酶链反应 　　中图分类号：R446 文献标识码：A 文章编号：2095-5200（2017）05-083-03 　　DOI：10.11876/mimt201705034 　　Investigation of infection rate of Group B Streptococcus in genital tract of late pregnant women and influence of vaginal microorganisms on infection Lan Huihua，Zhang ling，Wang Houzhao. （Department of Clinical Laboratory，Chenggong Hospital Affiliated to Xiamen University， Xiamen 361003，China） 　　[Abstract] Objective： The objective of this study was to investigate the infection rate of Group B Streptococcus （GBS） in genital tract of late pregnant women in this region， and to explore the influence of some vaginal microorganisms on GBS infection in pregnant women at the end of pregnancy. Methods： A total sample of 1228 cases of 35-37 weeks?pregnant women and 600 cases of 20-24 weeks?pregnant women from December 2014 to December 2015 were chosen. Vaginal 1/3 secretions and perianal secretions were taken and GBS was detected by fluorescent quantitative polymerase chain reaction （PCR）. The influence of detection of microorganisms in vaginal secretions of pregnant women on the detection rate of GBS was analyzed. Results： The total detection rate of GBS in genital tract of late pregnant women was 5.29% （65/1228）， and the total detection rate was 4.67% （28/600） in the second trimester， with no statistically significant difference between the two groups （P0.05）. In the late pregnancy， the detection rate of pregnant women in the 25-29