调控nk细胞杀伤肿瘤细胞免疫新分子的发现和机制分析-discovery and mechanism analysis of new molecules regulating nk cell killing tumor cell immunity.docx

- -2- HYPERLINK \l _bookmark0 实验二 非折叠蛋白反应诱导肝癌细胞抵抗 NK 细胞杀伤及分子机制 73 HYPERLINK \l _bookmark0 1 方法 ········································································································ 73 HYPERLINK \l _bookmark1 2 结果 ········································································································ 76 HYPERLINK \l _bookmark2 3 讨论 ········································································································ 87 HYPERLINK \l _bookmark3 小 结 ············································································································ 91 HYPERLINK \l _bookmark4 参考文献 ············································································································ 92 HYPERLINK \l _bookmark5 个人简历和研究成果 ······················································································ 103 HYPERLINK \l _bookmark5 个人简历 ······································································································ 103 HYPERLINK \l _bookmark6 博士研究生期间论文发表情况··································································· 104 HYPERLINK \l _bookmark6 SCI 论文 104 HYPERLINK \l _bookmark7 中文论文 ·································································································· 105 HYPERLINK \l _bookmark8 博士研究生期间参加会议情况··································································· 106 HYPERLINK \l _bookmark9 致 谢 ·········································································································· 107 - -1- 缩略语表 缩略词 英文全称 中文全称 ATF6 activating transcription factor 6 活化转录因子 6 CFSE 5- or 6-(N-Succinimidyloxycar- bonyl)-3  羧基荧光素二醋酸盐琥珀酰 亚胺酯 CHOP C/EBP homologous protein C/EBP 同源蛋白 DC dendritic cell 树突状细胞 eIF-2α eukaryotic initiation factor 2α 真核细胞起始因子 2α ER stress endoplasmic reticulum stress 内质网应激 ERAD ER-associated degradation 内质网相关降解 FAM carboxyfluorescein 羧基荧光素 FITC fluorescein isothiocyanate 异硫氰酸荧光素 GRP78 glucose-re