武汉市女性乳腺癌死亡率变化趋势及生存研究-study on the change trend and survival of female breast cancer mortality in wuhan city.docxVIP

华中科技大学博士学位论文 华 中 科 技 大 学 博 士 学 位 论 文 PAGE 4 PAGE 4 Study on Die Rate and survival analysis of Female Breast Cancer in Wuhan City Doctoral Candidate: Liu Bei Supervisor: Prof. Du Yukai ABSTRACT Objective To investigate the prevalence, treatment pattern and prognosis condition of women with breast cancer in Wuhan, and to explore the impact of demographic characteristics, clinical characteristics, socio-economic status on breast cancer survival, in order to recommend effective strategy for preventing the incidence of breast cancer and improving the quality of life of patients who suffered from the cancer, so as to ultimately reduce the prevalence and mortality of breast cancer, and improve quality of life of women. Methods Population-based, qualitative study combined with quantitative study method was adopted. The main qualitative study was literature review, mainly collecting data of women with breast cancer of different age groups at different regions from 2003 to 2008 in various large-scale surveys conducted in Wuhan and China; quantitative surveys used self-made questionnaire to carry out face-to-face interviews to patients with incipient breast cancer. All data were analyzed through statistical software SAS9.0 with descriptive analysis, χ2 test, nonparametric hypothesis testing, fitting univariate and multivariate COX proportional hazards regression models. Results Demographic characteristics Among the 204 women with breast cancer, the number of survival at the end of the study was 151, with a total survival rate as 74.02%; the number of death was 53, so the total mortality rate was 25.98%. Most of the women with breast cancer were diagnosed at age over 51 years old, the number of which was 132 (64.70%). The women who were diagnosed at age younger than 40 years old had the highest survival rate (88.89%). The mortality rates of various diagnosed age groups had statistically significant differences (χ2= 8.3270, P = 0.0039). The women with literacy of college or ab