皖北地区汉族人群fcrl-3基因单核苷酸多态性与gd的相关性研究-study on the relationship between single nucleotide polymorphism of fcrl - 3 gene and gd in han population in northern anhui.docxVIP

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皖北地区汉族人群fcrl-3基因单核苷酸多态性与gd的相关性研究-study on the relationship between single nucleotide polymorphism of fcrl - 3 gene and gd in han population in northern anhui.docx

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皖北地区汉族人群fcrl-3基因单核苷酸多态性与gd的相关性研究-study on the relationship between single nucleotide polymorphism of fcrl - 3 gene and gd in han population in northern anhui

别、甲状腺肿大程度、TpoAb、TgAb、Graves 有无突眼、甲状腺功能(FT3、FT4、 TSH)等临床特征在 AA、AG、GG 三种基因之间的差异性均无统计学意义（P0.05）（见表 8 ）。结论 1.FCRL-3 基因启动子-169 位点的 A/G 单核苷酸多态性与皖北地区汉族人群 GD 的发病有相关性，G 等位基因可能是 GD 的易感基因。 2.FCRL-3 基因启动子-169 位点的等位基因 G 可能与甲状腺疾病自身抗体 TRAb 的阳性有关，而与发病年龄、性别、眼征有无、甲状腺功能、TpoAb、TgAb 及甲状腺肿大程度无关。关键词 Graves 病；FCRL-3 基因;TRAb;单核苷酸多态性 2 PAGE PAGE 10 The association of FCRL-3 gene single nucleotide polymorphisms with Graves’ disease of Hans in the northern part of Anhui province Objective ABSTRACT Exploring the correlation between FCRL-3 gene single nucleotide polymorphisms with genetic susceptibility associated with GD in Han nationality located in the northern of ANHUI province by detecting allele and genotype frequency distributions of FCRL-3 gene promoter sites -169 A / G single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs ) in patients with diffuse toxic goiter (Graves disease, GD) and healthy control population . Further investigate the correlation between FCRL-3 gene promoter -169 locus A / G SNPs with GD ’s clinical features, including age, sex, degree of goiter , with or without Graves’ ophthalmopathy , thyroid stimulating hormone receptor antibody (TRAb) level , thyroid peroxidase antibody（TpoAb）, antithyroglobulin（TgAb） and thyroid function. Methods The experimental unrelated Han people which were born and lived in Northern Areas of ANHUI province were divided into GD group ( 180 cases ) and control group ( 146 cases ) . DNA was extracted from peripheral blood accompanied with the polymerase chain reaction - restriction fragment length polymorphism (PCR-RELP) genotype analysis was performd to compare group genotype and allele frequencies . Restriction enzyme was used to detect SNPs allele genotyping of GD patients and healthy controls chromosome 1 restriction FCRL-3 gene promoter sites region , then analyzed SNPs with GD susceptibility. Analyzing the association between SNPs allele genotyping and clinical indicators. Results The genotype frequency of FCR