替米沙坦对56肾切除大鼠肾组织pparγ和nnos表达的影响-effect of telmisartan on ppar γ and nnos expression in renal tissue of 56 nephrectomized rats.docxVIP

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替米沙坦对56肾切除大鼠肾组织pparγ和nnos表达的影响-effect of telmisartan on ppar γ and nnos expression in renal tissue of 56 nephrectomized rats.docx

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替米沙坦对56肾切除大鼠肾组织pparγ和nnos表达的影响-effect of telmisartan on ppar γ and nnos expression in renal tissue of 56 nephrectomized rats

华中科技大学硕士学位论文华中科技大学硕士学位论文 4 4 immunohistochemistry results showed that PPARγ mainly distributed in the areas of renal tubular epithelial cells, mesangial cells and infiltrating macrophages in rats with 5/6 nephrectomy. nNOS in renal cortex was mainly localized in dense patches, inner medullary collecting duct is also expressed. In the terms of the level of gene expression in the 5/6 nephrectomized rats kidney tissue, the expression of PPARγ and nNOS for mRNA and protein were decreased in the 5 groups except for the sham group, and they were higherly expressed in telmisartan group than in the telmisartan + GW9662 group (P0.05), while the relationship of nNOS and PPARγ protein expression in renal tissue telmisartan group and telmisartan + GW9662 group were in positive linear correlation (r = 0.865, P0.05). Conclusion: SD rats with 5/6 nephrectomy granted with telmisartan, can reduce glomerulosclerosis and renal interstitial fibrosis, thereby reducing the progress of chronic kidney disease. The mechanism may be related to upregulation of PPARγ, thus an increase in nNOS expression. This effect of Telmisartan may be independent of its angiotensin AT1 receptor antagonist effection. 【Key words】 telmisartan; peroxisome proliferators actived receptor γ; neuronal nitric oxide synthase; GW9662; chronic renal disease. 38 38 英文缩略词表 CKD chronic kidney disease 慢性肾脏病 ESRD end-stage renal disease 终末期肾脏疾病 PPARγ peroxisome proliferator activated receptors γ 过氧化物酶体增殖物激活受体 γ AngⅡ angiotensin Ⅱ 血管紧张素Ⅱ AT1 angiotensin type 1 receptor 血管紧张素受体 1 nNOS neuronal nitric oxide synthase 神经型一氧化氮合酶 eNOS endothelial nitric oxide synthase 内皮型一氧化氮合酶 iNOS inducible nitric oxide synthase 诱导型一氧化氮合酶 NO nitric oxide 一氧化氮 NADPH nicotinamide-adenine dinucleotide phosphate 还原型辅酶Ⅱ GFR glomeruar filtration rate 肾小球滤过率 TGF tubuloglomerular feedback 管球反馈 ACEI angiotensin-converting enzyme inhibitor 血管紧张素转化酶抑制剂 ARB angiotensin receptor blocker 血管紧张素受体阻滞剂 L-NAME L-N(G) nitr