无创正压通气的不同压力水平对人-机触发同步性的影响-influence of different pressure levels of noninvasive positive pressure ventilation on human-machine trigger synchronization.docxVIP

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无创正压通气的不同压力水平对人-机触发同步性的影响-influence of different pressure levels of noninvasive positive pressure ventilation on human-machine trigger synchronization.docx

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无创正压通气的不同压力水平对人-机触发同步性的影响-influence of different pressure levels of noninvasive positive pressure ventilation on human-machine trigger synchronization

广州医学院硕士论文广州医学院硕士论文 - - - PAGE 10 Effect of the different PS levels of non-invasive positive pressure ventilation on patient-ventilator trigger synchrony ABSTRACT Objective To investigate the effect of the different PS levels of non-invasive positive pressure ventilation on patient-ventilator trigger synchrony in healthy subjects and patients with acute exacerbation of chronic obstructive pulmonary disease in order to provide a theoretical basis of more rational clinical application in NPPV. Methods Eight healthy adults in Guangzhou Institute of Respiratory Disease received randomly the different PS levels(4cmH2O,8cmH2O,12cmH2O,16cmH2O and 20cmH2O respectively) of non-invasive positive pressure ventilation. Eight inpatients with acute exacerbation of COPD in Guangzhou Institute of Respiratory Disease received randomly low PS level , Optimal PS level and high low PS level of non-invasive positive pressure ventilation. The changes of inspiratory trigger time(TItri), trigger pressur-time product(PTPtri), respiratory center drive and ineffective triggering rate,etc were observed. Results Impact of PS levels on TItri. TItri(EMGdi), TItri(Pm), TItri(Peso) and TItri(Pdi) in healthy subjects increased with increasing PS levels(from 233.73±42.30 to 435.21±97.73ms, from 151.42±37.64 to 229.16±65.41ms, from 156.76±37.92 to 230.99±67.17ms and from 157.05±37.80 to 233.55±64.65ms respectively, P 0.05). At the same PS level, TItri(EMGdi) was longer than TItri(Pm), TItri(Peso) and TItri(Pdi) respectively in healthy subjects ( P 0.05) ,but the differences among TItri(Pm), TItri(Peso) and TItri(Pdi) were no statistics significance. TItri(EMGdi), TItri(Pm), TItri(Peso) and TItri(Pdi) in patients with chronic obstructive pulmonary disease. increased with increasing PS levels(from 241.38 ±37.88 to 375.73±68.62ms, from 174.44±38.77 to 225.69±85.03ms, from 164.30 ± 45.93 to 223.73 ± 80.58ms and from 161.80 ± 45.99 to 222.80 ± 78.21ms respectively, P 0.05). At the same PS