CerbB2在子宫内膜癌中表达及临床意义.doc

CerbB2在子宫内膜癌中表达及临床意义 　　【摘要】 目的 探讨C-erbB-2在子宫内膜癌中的表达及意义。方法 应用免疫组织化学染色S-P法,检测46例子宫内膜癌及30例非典型增生子宫内膜组织石蜡切片中C-erbB-2的表达情况,比较C-erbB-2蛋白表达与临床病理指标的关系及其意义。结果 30例非典型增生子宫内膜阳性表达18例,在46例子宫内膜癌患者中,C-erbB-2表达情况与子宫内膜癌FIGO分期I期-Ⅱ期与Ⅳ期间、病理学分级:I级与Ⅲ级间,淋巴结有无转移间有显著性差异(P0.05)。结论 FIGO分期晚、病理分级高,有淋巴结转移者C-erbB-2表达率高,C-erbB-2与子宫内膜癌预后有关。 　　【关键词】 C-erbB-2;子宫内膜癌;子宫内膜非典型增生;免疫组化 　　 　　Expression of C-erbB-2 in endometrial carcinoma and its clinical significance 　　 　　XU Zhi-ren,LV Xia-sheng,HU Jian-hua,et al. 　　Wu Jing zong dui Hospital Of Province,Jiang Xi Nanchang 330030,China 　　 　　【Abstract】 Objective To explore the expression and clinical significance of the C-erbB-2 in endometrial carcinoma.Methods The expression of C-erbB-2 in endometrial tissue form 46 patients with endometrium were detected by immunohistochemical S-P method.The relationship between the expression of C-erbB-2 and clinicopathological factors were also compared.Results The positive rate of C-erbB-2 in 30 patients with atypical hyperplasia of endometrium was 60%(18/30).The positive rates of C-erbB-2 expression in the m alignant tissue is higher than that in nonm alignant tissue(P0.05).The expression of C-erbB-2 was associated with International Federation of Gynecology and Obstetrics(FIGO) stages,pathological grades and the lymph node shift.And it wasnot concerned with age and the depth of mucosa infiltration.Conclusion The expression of C-erbB-2 correlates with the progress prognosis of endometrial carcinoma. 　　【Key words】 C-erbB-2; Endometrial carcinoma; Endometrial hyperplasia; Immunohistochemical 　　 　　子宫内膜癌是最常见的生殖道恶性肿瘤之一,目前子宫内膜癌的病因及发病机制尚不完全清楚。C-erbB-2是Shih等于1981年在大鼠脑细胞肿瘤中发现的一种癌基因,称为neu[1]。C-erbB-2癌基因编码一种具有酪氨酸激酶活性的跨膜糖蛋白,该蛋白属于生长因子受体家族,具有酪氨酸蛋白激酶的活性,而氨基酸的序列和结构与表皮生长因子受体同源,该蛋白可以抑制酪氨酸活性,在细胞的生长、增殖和分化过程中发挥作用,其过度表达与肿瘤的恶性程度有一定相关性[2]。C-erbB-2在乳腺癌中已成为常规检测指标,本文着重探讨C-erbB-2在子宫内膜腺癌中发生发展中的生物学意义,从临床及病理学角度探讨子宫内膜腺癌可能的发病机制和影响预后的因素,为子宫内膜腺癌的诊断、治疗和预后判断,尤其是为进一步开展子宫内膜腺癌基因靶向治疗提供实验依据。 　　1 资料与方法 　　1.1 一般资料 　　46例均来自本院1980年6月至2009年3月妇产外标本,其中子宫