不同血液净化方式对178例慢性肾功能衰竭尿毒症患者血管活性物质影响.docVIP

不同血液净化方式对178例慢性肾功能衰竭尿毒症患者血管活性物质的影响 　　【摘要】 目的：探讨血液透析和血液灌流两种血液净化方式对慢性肾功能衰竭尿毒症患者的血管活性物质的影响。方法：选取2013年2月-2015年2月于本院进行透析治疗的178例慢性肾功能衰竭尿毒症患者作为研究对象，按照硬币正反面分组法随机将其分为观察组和对照组，每组89例。对照组给予血液透析治疗，观察组给予血液灌流治疗，观察比较两组血管活性物质变化情况。结果：两组治疗前ET-1、AngⅡ、NO、Scr水平比较，差异均无统计学意义（P0.05）；治疗后，观察组ET-1、AngⅡ、NO、Scr水平均明显优于对照组，比较差异均有统计学意义（P0.05）；观察组的总满意率高于对照组，比较差异有统计学意义（P0.05）。结论：对慢性肾功能衰竭尿毒症患者使用血液灌流方式进行治疗可有效改善患者血管活性物质，提高患者对治疗的满意率，具有临床推广应用价值。 　　【关键词】 血液透析； 血液灌流； 慢性肾功能衰竭尿毒症患者； 血管活性物质； 影响 　　【Abstract】 Objective：To investigate the effect of hemodialysis and blood perfusion on vasoactive substances in patients with chronic renal failure and uremia.Method：178 chronic renal failure and uremia patients with dialysis treatment in our hospital from February 2013 to February 2015 were selected as the research objects.They were randomly divided into the observation group and the control group，89 cases in each group.The control group was treated with hemodialysis，the observation group was treated with blood perfusion.The changes of vasoactive substances in the two groups were compared.Result：Before treatment，the differences in the levels of ET-1，AngⅡ，NO and Scr between the two groups were not statistically significant（P0.05）.After treatment，the levels of ET-1，AngⅡ，NO and Scr in the observation group were better than those in the control group，the differences were statistically significant（P0.05）.The total satisfaction rate of the observation group was higher than that of the control group，the difference was statistically significant（P0.05）.Conclusion：Blood perfusion in patients with chronic renal failure and uremia is effective to improve patients’ vasoactive substances and improve the satisfaction rate of patients to the treatment.It has significant clinical promotion and application value. 　　【Key words】 Hemodialysis； Blood perfusion； Chronic renal failure and uremia patients； Vasoactive substances； Influence 　　First-author’s address：The Affiliated Hospital of He’nan Medical College，Zhengzhou 451191，China