免疫抑制剂环磷酰胺治疗急性间质性肾炎的临床效果.docVIP

免疫抑制剂环磷酰胺治疗急性间质性肾炎的临床效果 　　[摘要]目的 探?免疫抑制剂环磷酰胺治疗急性间质性肾炎的临床效果。方法 选取我院2015年6月～2017年4月收治的30例急性间质性肾炎患者作为研究对象，按治疗方式的不同分成对照组和治疗组，每组15例。对照组患者采用激素进行治疗，治疗组患者采用激素联合环磷酰胺免疫抑制剂治疗，比较两组患者的相关生化指标（主要包括血尿酸、血尿素氮、血肌酐、内生肌酐清除率）的改善情况、住院天数、不良反应发生率、治疗总有效率。结果 两组患者治疗前的血尿酸、血尿素氮、血肌酐、血肌酐清除率水平比较，差异无统计学意义（P0.05）。治疗组患者治疗后的血尿酸、血尿素氮、血肌酐等生化指标水平明显低于对照组，血肌酐清除率明显大于对照组，差异有统计学意义（P0.05）。治疗组患者的住院天数明显短于对照组，差异有统计学意义（P0.05）。治疗组患者的不良反应发生率为6.7%，明显小于对照组的13.3%，差异有统计学意义（P0.05）。结论 采用环磷酰胺免疫抑制剂对急性间质性肾炎患者进行治疗，能有效改善患者生化指标，从而快速促进患者肾功能恢复，且药效安全可靠。 　　[关键词]免疫抑制剂环磷酰胺；激素；急性间质性肾炎；临床效果 　　[中图分类号] R692.3 [文献标识码] A [文章编号] 1674-4721（2017）11（a）-0083-03 　　Clinical effect of immunosuppressant Cyclophosphamide in the treatment of acute interstitial nephritis 　　JIN Bi-hui WANG Cai-hong▲ 　　Department of Nephrology，Chifeng Municipal Hospital in the Inner Mongolia Autonomous Region，Chifeng 024000，China 　　[Abstract]Objective To investigate the clinical effect of immunosuppressant Cyclophosphamide in the treatment of acute interstitial nephritis.Methods 30 patients with acute interstitial nephritis who were admitted to our hospital from June 2015 to April 2017 were enrolled as the study subjects.According to the different treatment methods，the patients were divided into the control group and the treatment group，with 15 cases in each group.Patients in the control group were given hormones，and patients in the treatment group were given hormones combined with cyclophosphamide immunosuppressant.Improvement of relevant biochemical indicators （including serum uric acid，blood urea nitrogen，serum creatinine，endogenous creatinine clearance rate），the length of hospital stay，the incidence rate of adverse reactions，the total effective rate of treatment were compared between the two groups.Results There were no significant differences in the relevant biochemical indicators of serum uric acid，blood urea nitrogen，serum creatinine，endogenous creatinine clearance rate between the two groups before treatment （P0.05）.The level of serum uric acid，blood urea