不同剂量阿托伐他汀治疗心肌梗死合并心衰患者临床效果比较研究.docVIP

不同剂量阿托伐他汀治疗心肌梗死合并心衰患者的临床效果比较研究 　　【摘要】 目的：比较分析不同剂量阿托伐他汀治疗心肌梗死合并心衰患者的临床效果。方法：选择2015年4月-2016年4月在笔者所在医院接受治疗的心肌梗死合并心衰患者108例作为研究对象，按照不同用药剂量随机均分为低剂量组和高剂量组，每组54例，所有患者均采用阿托伐他汀进行治疗。其中，低剂量组为20 mg/d，高剂量组为40 mg/d，比较两组患者治疗前后心率、血浆B型脑钠肽、LVEF、LVDs、LVEd方面改善情况。结果：治疗前两组患者心率、血浆B型脑钠肽、LVEF、LVDs、LVEd比较差异无统计学意义（P0.05）；治疗后高剂量组心率、血浆B型脑钠肽、LVEF、LVDs、LVEd均优于低剂量组，差异均有统计学意义（P0.05）。结论：给予心肌梗死和并心衰患者采用高剂量阿托伐他汀治疗利于改善心功能，降低血浆B型脑钠肽水平，获得更加满意的效果，值得推广应用。 　　【关键词】 阿托伐他汀； 心肌梗死； 心衰； 临床疗效 　　doi：10.14033/j.cnki.cfmr.2018.10.012 文献标识码 B 文章编号 1674-6805（2018）10-0026-02 　　【Abstract】 Objective：To compare the clinical efficacy of different doses of Atorvastatin in the treatment of patients with myocardial infarction complicated with heart failure. Method：A total of 108 patients with myocardial infarction complicated with heart failure who were treated in the author’s hospital from April 2015 to April 2016 were randomly divided into low dose group and high dose group according to different dosage.All patients were treated with Atorvastatin.Among them， the low dose group was 20 mg/d，the high dose group was 40 mg/d，the heart rate，plasma B brain natriuretic peptide，LVEF，LVDs，LVEd improvement between two groups before and after treatment were compared.Result：There were no significant differences in heart rate，plasma B-type brain natriuretic peptide，LVEF，LVDs and LVEd before treatment between the two groups （P0.05）.After treatment the heart rate，plasma B-type brain natriuretic peptide，LVEF，LVDs，LVEd in high dose group were significantly better than low dose group，the differences were statistically significant（P0.05）.Conclusion：High dose of atorvastatin in patients with myocardial infarction and heart failure can improve the cardiac function and reduce the level of B-type brain natriuretic peptide，and obtain satisfactory results. It is worthy to be popularized and applied. 　　【Key words】 Atorvastatin； Myocardial infarction； Heart failure； Clinical efficacy 　　First-author’s address：People’s Hospital of Hanchuan City，Hanc