不同剂量辛伐他汀对Barrett食管患者食管癌预防效果分析.docVIP

不同剂量辛伐他汀对Barrett食管患者食管癌的预防效果分析 　　【摘要】 目的：探讨不同剂量辛伐他汀对Barrett食管患者食管癌的预防效果。方法：选取2004年1月-2009年1月期间收治的Barrett食管患者228例，按照随机数字表法分为A组、B组和C组，每组76例。所有患者均接受PPI治疗，A组和B组在PPI治疗的基础上分别加用辛伐他汀20 mg/d和40 mg/d，疗程为9个月，所有患者均获得为期5年的随访。统计分析三组Barrett食管疗效、食管癌发生情况和并发症发生情况。结果：A组、B组和C组治疗前后治疗效果为显著、好转和无效的患者比例及治疗有效率比较差异均无统计学意义（P0.05）。C组食管癌的发生率为13.16%，高于A组的6.58%和B组的5.26%，差异均有统计学意义（P0.05）。A组和C组慢性咳嗽、基底层细胞增生等并发症的发生率和总并发症发生率比较差异均无统计学意义（P0.05），B组肝功能异常和肌肉并发症的发生率及总并发症发生率均明显高于A组和C组，差异有统计学意义（P0.05）。结论：PPI治疗的基础上每日加用20 mg辛伐他汀用于治疗Barrett食管有效预防患者食管癌的发生且不会增加其并发症发生的风险，可作为预防食管癌发生辅助用药之一。 　　【关键词】 不同剂量； 辛伐他汀； Barrett食管； 食管癌； 预防 　　中图分类号 R735.1 文献标识码 A 文章编号 1674-6805（2015）23-0016-03 　　Prevention Effect of Different Doses of Simvastatin on Esophagus Cancer of Barrett’s Esophagus Patients/CAO Hui-qiong，GU Xin，MA Song-yan.// Chinese and Foreign Medical Research，2015，13（23）：16-18 　　【Abstract】 Objective：To explore the prevention effect of different doses of Simvastatin on esophagus cancer of Barrett’s esophagus patients. Method：228 patients with Barrett’s esophagus from January our hospital from January， 2004 to January， 2009 were divided into group A and group B and group C by digital random method， 76 cases in each group. All patients were treated with proton pump inhibitors（PPI）， and on the basis of PPI therapy， group A and group B combined with Simvastatin 20 mg/d and 40 mg/d respectively. All the patients received 5 years follow up. The treatment time was 9 months. Barrett’s esophagus cure effect， Barrett esophagus occurrence and complications occurrence of three groups were statistical analyzed.Result：Patients rate with significant， good， normal and bad curative effect and total treatment efficient in 3 groups had no statistical significance （P0.05）. Esophagus cancer incidence of group C was 13.16%， which were higher than the6.58% of group A and 5.26% of group B， and the difference was statistically significant （P0.05）. the incidence of chronic cough， base layer cell hyperplasia and other complications and total