不同浓度艾拉溶液对艾拉光动力疗法治疗尖锐湿疣影响.docVIP

不同浓度艾拉溶液对艾拉光动力疗法治疗尖锐湿疣的影响 　　【摘要】目的研究不同浓度艾拉溶液（5aminolevulinic acid solution，ALA）对光动力疗法治疗尖锐湿疣的影响。 　　方法选择门诊就诊的204例尖锐湿疣患者，随机分为三组，每组68例，1组采用10%ALA溶液，2组采用15%ALA溶液，3组采用20%ALA溶液进行光动力疗法治疗。比较三组治疗结束后的疗效和复发率。 　　结果三组疗效比较，2组、3组疗效显著优于1组，差异有统计学意义（P0.05）。6个月内三组复发率比较，2组、3组复发率显著低于1组（P0.05）。 　　结论艾拉光动力疗法治疗尖锐湿疣选择15%ALA溶液和20%ALA溶液疗效显著，且复发率低。但考虑经济原因，选择15%的ALA溶液不仅能有效治疗尖锐湿疣，还能降低治疗费用。 　　【关键词】尖锐湿疣；光动力疗法；艾拉溶液 　　【Abstract】ObjectiveTo investigate influence of the different concentrations of 5aminolevulinic acid solution （ALA） on photodynamic therapy in the treatment of condyloma acuminatum. 　　Methods204 outpatients with condyloma acuminatum were randomly divided into three groups， with 68 cases in each. Group 1 were treated with photodynamic therapy with 10% of ALA solution， Group 2 with 15% of ALA solution， and Group 3 with 20% of ALA solution.Then， effects and relapse rates of the three groups after treatment were compared， respectively. 　　Results Comparison between the three groups showed that effects of the Group 2 and the Group 3 were superior to that of the Group 1， and difference was statistically significant（P0.05）. Relapse rates of the Group 2 and the Group 3 within 6 months were obviously lower than that of the Group 1（P0.05）. 　　ConclusionPhotodynamic therapy with 15% and 20% of ALA solution in the treatment of condyloma acuminatum has obvious efficacy with few relapse rates. But， due to economic reasons， to choose 15% of ALA solution can not only effectively treat condyloma acuminatum， but also reduce the cost of treatment. 　　【Key words】condyloma acuminatum； photodynamic therapy； ALA solution 　　尖锐湿疣（Condyloma Acuminatum，CA）是指由人类乳头瘤病毒（Human Papillomavirus，HPV）感染所致的一种疣状增生性疾病，是临床常见的性传播疾病之一[1]，好发于人类外阴及肛周，具有发病率高、传染性强、易复发，甚至迁延难愈等特点。此病因涉及男女隐私常常导致患者害怕就诊而延误病情，病后可严重影响患者的身心健康。光动力疗法（Photodynamic Therapy，PDT）作为治疗尖锐湿疣的新技术，其治疗理念不仅仅局限于去除疣体，保证治愈率，而且在去除疣体的同时尽量提高安全性，减少副作用，降低复发率。光敏剂是光动力疗法发挥作用的重要因素之一，目前临床上最常用的光敏剂是以艾拉溶液（氨基酮戊酸，5aminolevulinic acid solution，ALA）为代表的第二代光敏剂，ALA可配制成不同浓度的溶液，浓度不同效果不一，且