中性粒细胞明胶酶相关脂质运载蛋白在单纯性肥胖儿童体内变化及意义.docVIP

中性粒细胞明胶酶相关脂质运载蛋白在单纯性肥胖儿童体内的变化及意义 　　【摘要】 目的 探讨单纯性肥胖儿童体内中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的变化及意义。方法 采用整群抽样法抽取7～18岁肥胖儿童90例， 按体质量指数（BMI）将其分为轻、中、重度肥胖组， 每组30例。同时以正常体重儿童30例作为健康对照组。对所有受试者测定空腹血糖（FBG）、血NGAL等相关指标水平， 并测定胰岛素抵抗指数（HOMA-IR）。结果 三组肥胖儿童FBG与健康对照组比较， 差异无统计学意义（P0.05）；轻度肥胖组儿童体内NGAL及HOMA-IR与健康对照组相比， 差异无统计学意义（P0.05）；中、重度肥胖组儿童体内NGAL及HOMA-IR均高于健康对照组， 差异有统计学意义（P0.05）。结论 明显的肥胖可影响儿童体内中性粒细胞明胶酶相关脂质运载蛋白、胰岛素等激素水平的分泌， 是其日后出现胰岛素抵抗、甚至发展为糖尿病的可能原因。 　　【关键词】 单纯性肥胖；儿童；中性粒细胞明胶酶相关脂质运载蛋白；胰岛素抵抗指数；糖尿病 　　DOI：10.14163/j.cnki.11-5547/r.2015.25.001 　　【Abstract】 Objective To investigate change and significance of neutrophil gelatinase-associated lipocalin （NGAL） in children with simple obesity. Methods A total of 90 obesity children aging 7～18 years old in cluster sampling method were divided by their body mass index （BMI） into mild obesity group， moderate obesity group and severe obesity group （FBG）， and each group contained 30 cases. There were another 30 healthy children as healthy control group. Fasting blood glucose（FBG）， NGAL and insulin resistance （HOMA-IR） index were detected in all subjects. Results Compared with the healthy control group， the three obesity groups had no statistical significance in FBG （P0.05）. NGAL and HOMA-IR index had no statistically significant difference between the mild obesity group and the healthy control group （P0.05）. The moderate and severe obesity groups had higher NGAL and HOMA-IR index than the healthy control group， and their difference had statistical significance （P0.05）. Conclusion Neutrophil gelatinase-associated lipocalin and secretion of insulin can be influenced by obvious obesity， which is the potential cause of future insulin resistance and diabetes mellitus. 　　【Key words】 Simple obesity； Children； Neutrophil gelatinase-associated lipocalin； Insulin resistance index； Diabetes mellitus 　　儿童单纯性肥胖（childhood simple obesity， CSO）一般由遗传与环境因素等共同作用引起， 与代谢性疾病如胰岛素抵抗、葡萄糖耐量减低及2型糖尿病的发病风险上升有关。其中胰岛素抵抗（insulin resistance， IR）是最常见的肥胖相关代谢性疾病， 可作为肥胖致病的中间环节， 增加糖尿病、高血压、心血管疾病、代