中西医结合治疗老年单纯收缩期高血压多中心随机双盲对照临床研究.docVIP

中西医结合治疗老年单纯收缩期高血压的多中心随机双盲对照临床研究 　　[摘要] 目的 比较分析中医及中西医结合治疗老年单纯收缩期高血压的临床效果差异。 方法 选择我院住院部2015年8月～2016年1月间收治的老年单纯收缩性高血压患者80例作为观察对象，按照入院编号奇偶性方法进行分组，分别将40例患者纳入对照组、观察组中。对照组患者用中医方案治疗，观察组患者用中西医结合方案治疗。观察血压变化以及用药期间安全性及两组患者经不同用药方案治疗后在临床效果方面的差异。 结果 治疗后，观察组SBP为（141.2±5.6）mmHg，显著低于对照组，差异有统计学意义（P0.05）。两组患者用药期间不良反应发生率比较差异无统计学意义（P0.05）。结论 中西医结合治疗老年单纯收缩期高血压的效果确切，可短期内降低患者SBP水平，且用药期间不良反应轻微，兼具安全性价值，值得临床推广应用。 　　[关键词] 高血压；收缩期；中西医结合；中医；老年患者 　　[中图分类号] R544.1；R259 [文献标识码] B [文章编号] 1673-9701（2016）11-0125-03 　　[Abstract] Objective To compare and analyze the clinical effects of traditional Chinese medicine （TCM） and integrated traditional Chinese medicine and western medicine（TCM-WM） in treatment of isolated systolic hypertension（ISH） in elderly patients. Methods 80 elderly patients with ISH treated in our hospital from August 2015 to January 2016 were selected and divided based on odd or even admission number into control group and observation group， each with 40 cases. Patients in the control group were treated by TCM， while patients in the observation group were treated by integrated TCM-WM. The changes of blood pressure and safety during treatment were observed to compare the clinical effects of the two therapies. Results After treatment， the detected value of SBP was （141.2±5.6） mmHg in the observation group， which was significantly lower than that in the control group （P0.05）. There was no significant difference in incidence of adverse reactions between two groups （P0.05）. Conclusion Integrated TCM-WM therapy has confirmed effect on ISH in elderly patients， and can reduce the SBP of patients in a short period with low incidence of adverse reactions and favorable safety， thus is worthy to be promoted. 　　[Key words] Hypertension； Systole； Integrated traditional Chinese medicine and western medicine； Traditional Chinese medicine； Elderly patient 　　报道显示老年单纯收缩期高血压致病原因与大动脉顺应性减退以及周围血管阻力异常升高等因素相关，但患者血液流动与压力基本维持在正常状态下[1-4]。中医观点则认为老年单纯收缩期高血压的形成与“气血冲和”密切相关[5-7]。因此，临床有大量研究在尝试通过中西医结合的方式提高对老年单纯收缩期