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T h e n e w e ngl a nd j o u r na l o f m e dic i n e
Original Article
Adjuvant Pertuzumab and Trastuzumab
in Early HER2-Positive Breast Cancer
Gunter von Minckwitz, M.D., Marion Procter, Ph.D., Evandro de Azambuja, M.D.,
Dimitrios Zardavas, M.D., Mark Benyunes, M.D., Giuseppe Viale, M.D., Thomas Suter, M.D.,
Amal Arahmani, Ph.D., Nathalie Rouchet, M.Sc., Emma Clark, M.Sc., Adam Knott, Ph.D.,
Istvan Lang, M.D., Christelle Levy, M.D., Denise A. Yardley, M.D., Jose Bines, M.D.,
Richard D. Gelber, Ph.D., Martine Piccart, M.D., and Jose Baselga, M.D.,
for the APHINITY Steering Committee and Investigators*
A BS TR AC T
BACKGROUND
The authors’ affiliations are listed in the Pertuzumab increases the rate of pathological complete response in the preoperative
Appendix. Address reprint requests to context and increases overall survival among patients with metastatic disease when
Dr. von Minckwitz at the German Breast
Group, GBG Forschungs, Martin-Behaim- it is added to trastuzumab and chemotherapy for the treatment of human epidermal
Str. 12, 63263 Neu-Isenburg, Germany, or growth factor receptor 2 (HER2)–positive breast cancer. In this trial, we investigated
at gunter.vonminckwitz@gbg.de, or to whether pertuzumab, when added to adjuvant trastuzumab and chemotherapy, im-
Dr. Baselga at Memorial Sloan Kettering
Cancer Cent
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