利拉鲁肽联合二甲双胍治疗42例2型糖尿病临床效果分析.docVIP

利拉鲁肽联合二甲双胍治疗42例2型糖尿病临床效果分析 　　【摘要】 目的：分析利拉鲁肽联合二甲双胍治疗2型糖尿病的临床效果。方法：对2014年12月-2015年12月在笔者所在医院就诊的84例2型糖尿病患者按照随机数表法随机的分为对照组和试验组，每组42例；对照组患者给予二甲双胍治疗，试验组患者给予利拉鲁肽联合二甲双胍进行治疗，比较两组患者治疗前后血糖水平及临床效果。结果：（1）治疗后，两组患者空腹血糖、餐后2 h血糖和糖化血红蛋白指标与治疗前比较，差异均有统计学意义（P0.05）；治疗后，试验组空腹血糖、餐后2 h血糖和糖化血红蛋白分别为（6.01±0.84）、（8.35±1.24）mmol/L和（10.21±2.78）%，均显著的优于对照组患者（P0.05）。（2）对照组中有11例（26.19%）患者无效，31例患者有效和显效，总有效率为73.81%；试验组中，有2例患者无效，有40例患者有效和显效，总有效率为95.24%。试验组的总有效率显著高于对照组（P0.05）。结论：利拉鲁肽联合二甲双胍可以有效的控制患者空腹、餐后2 h血糖水平，临床治疗效果较好，在临床中具有推广和应用价值。 　　【关键词】 利拉鲁肽； 二甲双胍； 2型糖尿病； 血糖水平 　　doi：10.14033/j.cnki.cfmr.2017.12.004 文献标识码 A 文章编号 1674-6805（2017）12-0008-03 　　【Abstract】 Objective：To analyze the clinical effect of Liraglutide combined with Metformin in the treatment of type 2 diabetes mellitus.Method：84 patients with type 2 diabetes mellitus in our hospital from December 2014 to December 2015 were randomly divided into control group and experimental group，with 42 patients in each group.The control group was treated with Metformin，the experimental group was given Liraglutide combined with Metformin for treatment.The blood glucose levels before and after treatment and the clinical results were compared between the two groups of patients.Result：（1）There were significant differences in fasting blood glucose，2-hour postprandial blood glucose and glycosylated hemoglobin of the two groups between before treatment and after treatment（P0.05）.After treatment，the fasting blood glucose，2-hour postprandial blood glucose and glycosylated hemoglobin of the experimental group was （6.01±0.84）mmol/L，（8.35±1.24）mmol/L，and （10.21±2.78）% respectively，which were significantly better than those of the control group（P0.05）.（2）In the control group，11 patients（26.19%） were ineffective，31 patients were effective and markedly effective rate was 73.81%；in the experimental group，2 patients were ineffective，40 patients were effective and markedly effective rate was 95.24%.The effective rate of the experimental group was significantly higher than