利拉鲁肽对比甘精胰岛素治疗肥胖2型糖尿病临床观察.docVIP

利拉鲁肽对比甘精胰岛素治疗肥胖2型糖尿病临床观察 　　[摘要] 目的 探?利拉鲁肽对比甘精胰岛素治疗肥胖2型糖尿病的临床疗效。 方法 纳入40例我院就诊的二甲双胍单药治疗效果不佳的肥胖2型糖尿病患者，随机分为实验组、对照组，实验组给予利拉鲁肽针，对照组给予甘精胰岛素针。观察两组治疗前及治疗12周后空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三脂、体重指数、胰岛细胞功能指数（Homa-β）和胰岛素抵抗指数（Homa-IR）及记录不良反应事件。 结果 经12周治疗后，两组患者空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数较治疗前明显下降，胰岛β细胞功能指数明显升高，与治疗前相比差异有统计学意义（P0.05）；治疗后实验组体重指数、胆固醇、甘油三脂与治疗前相比差异有统计学意义（P0.05）。 结论 利拉鲁肽和甘精胰岛素均可有效改善肥胖2型糖尿病患者的血糖、糖化血红蛋白等指标，改善胰岛β细胞功能，低血糖发生率及胃肠道反应均较低，利拉鲁肽比甘精胰岛素更能有效地降低患者的体重，改善血脂，更适合肥胖的2型糖尿病患者。 　　[关键词] 2型糖尿病；肥胖；利拉鲁肽；甘精胰岛素 　　[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2017）10-0031-04 　　Clinical comparative observation of Liraglutide compared with insulin glargine in the treatment of obesity type 2 diabetes mellitus 　　XIE Fei1 LUO Lin2 RUAN Lingyan1 WANG Xiaojing1 WANG Liqun1 　　1.Department of Endocrinology， Ningbo Yinzhou Second Hospital， Ningbo 315100， China； 2.Ningbo University School of Medicine， Ningbo 315211， China 　　[Abstract] Objective To investigate the clinical efficacy of liraglutide compared with insulin glargine in the treatment of obesity type 2 diabetes mellitus. Methods 40 patients with obese type 2 diabetes mellitus who were treated with metformin monotherapy with poor efficacy in our hospital were randomly divided into control group and experimental group. The experimental group was treated with liraglutide injection and the control group was given insulin glargine needle. The levels of fasting blood glucose， 2-hour postprandial blood glucose， glycosylated hemoglobin， total cholesterol，triglyceride， body mass index， islet cell function index（Homa-β）， insulin resistance index （Homa-IR） and adverse events were measured before and after 12 weeks of treatment. Results After 12 weeks of treatment， the fasting blood glucose， 2-hour postprandial blood glucose， glycosylated hemoglobin and insulin resistance index in both groups were significantly lower than those before treatment， and the β-cell function index significantly increased， significantly different from those before treatme