奥曲肽联合凝血酶治疗肝硬化合并上消化道出血临床效果研究.docVIP

奥曲肽联合凝血酶治疗肝硬化合并上消化道出血临床效果研究 　　[摘要]目的 探讨奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的临床效果。方法 选取本院2014年12月～2016年12月收治的60例肝硬化合并上消化道出血患者，并采用抽签的方式将其分为两组，两组患者均接受营养支持等常规治疗，基于此，对照组30例患者采用奥曲肽治疗，观察组30例患者采用奥曲肽联合凝血酶治疗，比较两组患者的成功止血率、平均住院时间、再出血率以及平均止血时间。结果 观察组患者的平均止血时间为（18.3±3.3）h，短于对照组的（27.6±4.0）h（P0.05）；观察组患者的平均住院时间为（7.2±2.9）d，明显短于对照组的（9.6±5.6）d （P0.05）；观察组患者的止血成功率100.00%，高于对照组的73.33%（P0.05）；观察组患者的再出血率为3.33%，低于对照组的26.67%（P0.05）。结论 肝硬化合并上消化道出血采用奥曲肽联合凝血酶的治疗效果显著，可使患者的止血时间明显缩短，使其再出血率显著降低，使其止血成功率进一步提高。 　　[关键词]奥曲肽；凝血酶；肝硬化合并上消化道出血；临床效果 　　[中图分类号] R657.3+1 [文献标识码] A [文章编号] 1674-4721（2017）04（b）-0140-03 　　Clinical effect study of Octreotide combined with Thrombin treating cirrhosis complicated with upper gastrointestinal bleeding 　　ZHOU Xiao-yu 　　Department of Gastroenterology，Qidong People′s Hospital in Jiangsu Province，Qidong 226200，China 　　[Abstract]Objective To study the clinical effect of Octreotide combined with Thrombin treating cirrhosis complicated with upper gastrointestinal bleeding.Methods A total of 60 patients with cirrhosis complicated with upper gastrointestinal bleeding treated in our hospital from December 2014 to December 2016 were selected.By drawing lots，they were divided into two groups.Regular treatment like nutritional support was provided in both groups.Besides，in the control group （n=30），Octreotide was provided，and in the observation group （n=30），Octreotide combined with Thrombin was applied.The success rate of hemostasis，average hospital stay，rebleeding rate and mean hemostatic time were compared between the two groups.Results The average hemostasis time in the observation group was （18.3±3.3） h，and it was less than that in the control group [（27.6±4.0） h] （P0.05）.The average hospital stay in the observation group was （7.2±2.9） d and was shorter than the control group [（9.6±5.6） d] （P0.05）.The success rate of hemostasis in the observation group was 100.00%，and it was much higher than that in the control group accounting for 73.33% （P0.05）.The rebleeding rate in the observation