重症肺炎外周血单核细胞tlr2 4表达与血浆tnf-α il-1β il-8水平的相关性-correlation between tlr 24 expression in peripheral blood mononuclear cells and plasma tnf - α il - 1β il - 8 level in severe pneumonia.docxVIP

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重症肺炎外周血单核细胞tlr2 4表达与血浆tnf-α il-1β il-8水平的相关性-correlation between tlr 24 expression in peripheral blood mononuclear cells and plasma tnf - α il - 1β il - 8 level in severe pneumonia.docx

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重症肺炎外周血单核细胞tlr2 4表达与血浆tnf-α il-1β il-8水平的相关性-correlation between tlr 24 expression in peripheral blood mononuclear cells and plasma tnf - α il - 1β il - 8 level in severe pneumonia

重症肺炎外周血单核细胞TLR2 重症肺炎外周血单核细胞TLR2、4表达与血浆TNF-a、IL-1?、IL-8水平的相关性 PAGE PAGE 5 肺炎组外周血单核细胞上 TLR4 的表达明显高于肺炎组，并且与 PSI 评分存在正相关，说明 TLR4 的表达与肺炎的严重程度密切相关。关键词：重症肺炎；Toll 样受体；细胞因子；单核细胞. The expression of TLR2、4 in PBMC from Severe Pneumonia and Correlated with the levels of TNF-α, IL-1β, IL-8 in Plasma Major: Respiratory Medicine M.D. Candidate : XU He-ping Supervisor: Prof. ZHAO Zi-wen Abstract Background Severe pneumonia are bacteria, viruses microbial invasion of the body as the main cause of the inflammation after the signal transduction of immune disorders, induced by TNF-α, IL-1β and IL-8 and other pro- inflammatory cytokine over-activation, trigger inflammation ultimately trigger a cascade of inflammatory cytokines and systemic inflammatory response syndrome (SIRS). What causes the over expression of inflammatory cytokines? There is no good explanation. Recently，the discovery of TLRs have a significant development in rnatural immunity research, has proved that the receptor plays an important role in the immune infection [1]. TLR2、 4 in the TLR family occupies an important position, it was found that infectious disease known as immune mechanisms important milestone in the study. TLRs recognize their ligands, the activation of NF-ΚB such as transcription factors and protein kinases, release of inflammatory mediators, activation of innate immunity; but also to antigen-presenting cells of costimulatory molecules CD80, CD86, and eventually start the PAGE PAGE 10 follow-up of T cells, B cell-mediated specific immune [2] TLR2, 4 as an important inflammatory receptors, mainly distributed in the marrow- derived mononuclear cells in patients with clinical severe pneumonia expressed in monocytes and the expression of inflammatory cytokines, has not been reported to be studied further. Objective At the protein level and mRNA molecules of severe pneumonia in peripheral blood mononuclear cells, preliminary study TLR2, 4 expression in the inflammatory response