子宫内膜样腺癌中id 1 smad4和p21waf1cip1蛋白和mrna的表达及意义-expression and significance of id 1 smad 4 and p 21 wa f1 cip 1 protein and mrna in endometrial adenocarcinoma.docxVIP

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子宫内膜样腺癌中id 1 smad4和p21waf1cip1蛋白和mrna的表达及意义-expression and significance of id 1 smad 4 and p 21 wa f1 cip 1 protein and mrna in endometrial adenocarcinoma.docx

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子宫内膜样腺癌中id 1 smad4和p21waf1cip1蛋白和mrna的表达及意义-expression and significance of id 1 smad 4 and p 21 wa f1 cip 1 protein and mrna in endometrial adenocarcinoma

安徽医科大学硕士学位论文陈晶晶安徽医科大学硕士学位论文陈晶晶．2010 PAGE 5 PAGE 5 为的有用指标。3.在子宫内膜样腺癌组织中P21WAF1/CIP1表达明显高于正常内膜、高分化癌高于低分化癌、浅肌层浸润高于深肌层浸润和Ⅰ期-Ⅱ期高于Ⅲ期及以上分期， P21WAF1/CIP1可能对的生物学行为和转归起一定作用，它的表达可作为临床判断EA预后的潜在指标。4.子宫内膜样腺癌的发生是由多种基因共同参与和协同作用的结果， Id-1、Smad4和P21WAF1/CIP1在子宫内膜样腺癌的发生发展不同阶段均起着重要的作用，它们的表达异常有可能成为判断子宫内膜组织癌变和转移及预后的重要指标，为临床肿瘤治疗提供理论依据。关键词子宫内膜样腺癌 Id-1 Smad4 P21WAF1/CIP1 Expressions of Id-1、Smad4 and P21WAF1/CIP1 protein and mRNA in endometrioid adenocarcinoma and their significance Abstract Objective To detect the protein and mRNA expression of inhibitor of DNA binding and/or differentiation-1(Id-1), deleted in pancreatic cancer locus 4 (DPC4/Smad) and P21WAF1/CIP1 in tissues from endometrioid adenocarcinoma,endometrial hyperplasia and normal endometrium.To investigate their roles in carcinogenesis, biological behavior and to evaluate their clinicopathologic significance. Methods The expression levels of Id-1, Smad4 and P21WAF1/CIP1proteins and mRNA in endometrioid adenocarcinoma tissues(n=72),endometrial hyperplasia tissues (n=60) and normal tissues (n=30) were examined by immunohistochemistry and in situ hybridization method. Results 1. The positive rates of Id-1, Smad4 and P21WAF1/CIP1protein and mRNA in endometrioid adenocarcinoma were respectively 86.1%(62/72) 、 44.4%(32/72) 、 63.9%(46/72) 、 73.6%(53/72)、41.7%(30/72) and 61.1%(44/72). 2. The positive rates of Id-1 and P21WAF1/CIP1 protein and mRNA in endometrioid adenocarcinoma tissues were significantly higher than that in normal endometrium and endometrial hyperplasia(P0.05)，The positive expression of Id-1 was related to the histological grade(P0.01), FIGO stage (P0.01), depth of invasion(P0.05) and lymph node metastasis(P0.05). The positive expression of P21WAF1/CIP1 was related to the histological grade(P0.05), FIGO stage(P0.01) and depth of invasion (P0.05). 3.The protein and mRNA expression of Smad4 was significantly weak in endometrioid adenocarcinoma tissues,which was negatively c