持续恒温循环腹腔热灌注化疗治疗腹腔恶性肿瘤初步应用.docVIP

持续恒温循环腹腔热灌注化疗治疗腹腔恶性肿瘤初步应用 　　【摘要】 目的：研究持续恒温循环腹腔热灌注化疗（Constant temperature hyperthermic peritoneal perfusion chemotherapy，CTHPPC）治疗腹腔恶性肿瘤的临床效果。方法：选取2013年11月-2015年6月本院收治的胃肠道恶性肿瘤患者98例作为研究对象，随机分为对照组与试验组，每组49例。对照组行单纯手术及术后化疗，试验组在对照组的基础上行CTHPPC，比较两组患者的临床治疗效果和生活质量评分情况。结果：试验组的治疗总有效率为93.88%，明显高于对照组的71.43%，比较差异有统计学意义（P0.05）；试验组生活质量评分为（56.33±1.25）分，高于对照组的（47.48±5.56）分，比较差异有统计学意义（P0.05）。结论：CTHPPC治疗腹腔恶性肿瘤临床疗效显著，能有效提高治疗有效率和生存率，改善患者的生活质量，值得临床推广应用。 　　【关键词】 持续恒温循环腹腔热灌注化疗； 腹腔恶性肿瘤； 临床疗效 　　【Abstract】 Objective：To study the clinical effect of constant temperature hyperthermic peritoneal perfusion chemotherapy in treatment of malignant tumor for the abdominal cavity.Method：A total of 98 cases of gastrointestinal cancer patients in our hospital from November 2013 to June 2015 were selected as the research objects，they were randomly divided into the control group and experimental group，each group had 49 cases.The control group was treated with simple operation and postoperative chemotherapy，the experimental group were treated with CTHPPC on the basis of the control group，the clinical treatment effect and quality of life in two groups were compared.Result：The total effective rate of the experimental group was 93.88%，significantly higher than 71.43% of the control group，the difference was statistically significant（P0.05）.The score of quality of life in the experimental group was （56.33±1.25），which was higher than （47.48±5.56） of the control group，the difference was statistically significant（P0.05）.Conclusion：CTHPPC in the treatment of abdominal malignant tumor clinical curative effect is remarkable，can increase the treatment effective rate and survival rate of patients，improve the quality of life，it is worthy of clinical application. 　　【Key words】 CTHPPC； Peritoneal cancer； Clinical curative effect 　　First-author’s address：The People’s Hospital of Yingde City，Yingde 513000，China 　　doi：10.3969/j.issn.1674-4985.2016.15.012 　　近年来，腹腔恶性肿瘤的发病率呈上升趋势。虽然诊断和治疗技术不断提高，但仍有大量患者确诊时已出现腹腔广泛种植转移或根治性切除术后