正常男性体重指数与睾酮和雌二醇关系探讨.docVIP

正常男性体重指数与睾酮和雌二醇关系探讨 　　【摘要】 目的 探讨正常男性体重指数(BMI)与睾酮(T)、雌二醇(E?2)的关系。方法 收集因不孕症就诊的夫妻中男性正常者43例,检测其BMI和血清T、E?2水平。结果 43例男性的平均BMI 29?6 kg/m??2?。有生育史的男性的BMI(26?7 ±6?1)kg/m?2明显低于无生育史的男性的BMI(31?7±5?3)kg/m?2(P0?01)。有生育史的男性的血清T水平(19?1±4?1)nmol/L明显高于无生育史的男性的血清T水平(16?7±3?1)nmol/L(P0?05)。有生育史的男性的血清E?2水平(79?2±24?2)pmol/L明显低于无生育史的男性的血清E?2水平(105?3±24?7)pmol/L(P0?01)。BMI与血清T水平成负相关(r=?0?807,P0?001),与血清E?2水平成正相关(r=0?684,P0?001)。结论 BMI的增加是男性生育力下降的影响因素之一。? 　　【关键词】 　　男性;体重指数;睾酮;雌二醇 　　 　　The association of BMI and testosterone and estradiol in normal men 　　 　　CHEN Wei?zhen, PENG Qi?cai, LUO Hui? 　　Department of Nuclear Medicine, Department of Obstetrics Gynecology,the Third Affiliated Hospital of Sun Yat?sen University, Guangzhou 510630, China 　　? 　　【Abstract】 Objective To explore the association of body mass index (BMI) and serum testosterone (T) and estradiol (E?2) in normal men? Methods There were total 43 cases of normal men who were seeking fertility assistance? Their BMI, serum testosterone and estradiol was measured? Results The mean BMI of 43 men was 29?6 kg/m?2.BMI in male with paternity (26?7±6?1)kg/m?2 was lower than that of male without (31?7±5?3)kg/m?2(P0?01)? Serum T level in male with paternity (19?1±4?1)nmol/L was higher than that of male without (16?7±3?1)nmol/L(P0?05? Serum E?2 level in male with paternity (79?2±24?2)pmol/L was lower than that of male without (105?3±24?7)pmol/L) (P0?01)? BMI was negatively correlated with serum T level (r=?0?807, P0?001), while positively correlated with serum E?2 level (r=0?684, P0?001)?Conclusion The increase of BMI maybe one of the risk factors of decreased male fertility?? 　　【Key words】 　　Male;Body index mass;Testosterone;Estradiol 　　 　　在所有不孕症患者者,约有半数是男性因素导致的??[1]?。因不孕症就诊的男性中有40%是肥胖患者??[2]?。肥胖的不孕症男性患者比非肥胖的不孕症男性患者的睾酮、性激素结合球蛋白、睾酮/雌二醇比值均低??[3]?。但是非不孕症的肥胖男性的生育能力却研究的甚少。本研究通过探讨正常男性BMI与血清睾酮和雌二醇的关系,以研究超重和肥胖对正常男性生育能力的影响。? 　　1 材料和方法? 　　1?1 临床资料 收集因不孕症就诊的夫妻中,男方正常的患者43例,年龄22~45岁,平均34?3岁。所有受检者均经系统检查提示男方的生育能力基本正常。? 　　1?2 方法? 　　1?2?1