环磷酰胺联合激素治疗系统性红斑狼疮患者可行性研究.docVIP

环磷酰胺联合激素治疗系统性红斑狼疮患者可行性研究 　　[摘要] 目的 探讨环磷酰胺联合激素治疗系统性红斑狼疮（SLE）的疗效及安全性。 方法 选取2010年1月～2016年3月在我院的40例SLE患者。随机分为研究组和对照组，各20例。对照组采用糖皮质激素治疗，研究组给予环磷酰胺联合糖皮质激素治疗。采用SF-36生活质量量表调查患者的生活质量。对两组患者治疗前后的疾病活动指数、C3、SCr、尿蛋白、BUN改善情况、生活质量评分及不良反应情况进行综合比较。 结果 研究组患者疾病活动指数为（3.57±0.89），较对照组的（5.06±1.25）优（P0.05）。 结论 环磷酰胺联合激素治疗系统性红斑狼疮效果确切，用药安全性高，有助于改善患者的肾功能，促进预后显著好转，提高生活质量，值得临床推广。 　　[关键词] 环磷酰胺；激素；系统性红斑狼疮；生活质量 　　[中图分类号] R593.241 [文献标识码] B [文章编号] 2095-0616（2016）20-40-03 　　Feasibility study of cyclophosphamide combined with steroid therapy in treatment of patients with systemic lupus erythematosus （SLE） 　　WEI Jianbo NING Fangfang LU Qinyan 　　Department of Kidney Internal Medicine，the Sixth Affiliated Hospital of Guangzhou Medical University，Qingyuan 511518，China 　　[Abstract] Objective To investigate effect and safety of cyclophosphamide combined with steroid therapy in treatment of patients with systemic lupus erythematosus （SLE）. Methods 40 cases of SLE in our hospital were randomly divided into research group and control group， 20 cases each group. Patients in control group were treated with steroid therapy， and patients in research group were treated with cyclophosphamide combined with steroid therapy. SF-36 quality of life scale was uesd to evaluate life quality. The improvement of disease activity index， C3， SCr， urinary protein， BUN， quality of life scores and adverse reaction of two groups were compared. Results The disease activity index of research group was （3.57±0.89）， which was better than （5.06±1.25） of control group （P0.05）. Conclusion Cyclophosphamide combined with steroid therapy in treatment of patients with SLE is effective and safety. It can improve renal function， promote the prognosis， and improve life quality. It is worthy of clinical widely use. 　　[Key words] Cyclophosphamide；Steroid therapy；Systemic lupus erythematosus；Quality of life 　　系统性红斑狼疮（SLE）是临床常见的自身免疫性疾病，血清内存在多种自身抗体，临床表现多种多样，以炎性反应和血管异常为主要病理改变，对神经系统、血液系统、消化系统等均可造成程度不等的损害，严重影响患者的生活质量[1]。环磷酰胺具有显著免疫抑制作用，联用糖皮质激素能有效