环磷酰胺注射液治疗难治性肾病综合征临床观察.docVIP

环磷酰胺注射液治疗难治性肾病综合征临床观察 　　摘要：目的：观察环磷酰胺注射液治疗难治性肾病综合征（Refractory nephrotic syndrome，RNS）的治疗效果。方法：抽取了在我院就诊56例RNS病人，将其分为观察组和对照组，观察组采取环磷酰胺（Cyclophosphamide，CTX）注射液治疗，对照组使用常规激素治疗。结果：观察组的治疗总有效率（75%）大于对照组（32.1%）。在观察组病人中，有胃肠道反应的患者有2例，经过停药和对症治疗，都恢复正常；对照组有8例病人有呼吸道感染不良症状产生，有6例胃肠道反应的病人，经停药及治疗后，不良症状消失。结论：CTX治疗RNS的治疗效果明显，出现较少的不良症状，具有临床实用价值。 　　关键词：难治性肾病综合征； 环磷酰胺；治疗； 临床观察 　　Abstract：Objective To explore the clinical efficacy of cyclophosphamideinjection in the treatment of refractory nephrotic syndrome.Methods 56 patients with refractory nephrotic syndrome in our hospital were randomly divided into observation group and control group （n = 28）. The control group received conventional hormone， the observation group received cyclophosphamide injection. The clinical efficacy of the two groups were observed and compared. Results The complete remission rate and total effective rate in the observation group were higher than those in the control group， and the ineffective rate in the observation group was lower than that in the control group. In the observation group， two patients occurred gastro-intestinal reactions. Their physiological Indexes have returned to normal after receiving appropriate treatment；Inthe control group， 8 patients occurred respiratory infection， six patients occurred gastrointestinal reactions. Theiradverse symptomshave disappeared are after stopping treatment.ConclusionsCyclophosphamide injection in the treatment of refractory nephrotic syndrome has good curative effect， low recurrence rate and fewer side effects. 　　KeyWords：RefractoryNephrotic Syndrome； Cyclophosphamide； Treatment； Clinical Study 　　RNS是肾病综合症病人在使用正规激素疗程的疗效差或者难以停药或者病情经常复发，难以忍受不良症状而无法再用药的肾病综合征[1]。目前，由于RNS的治疗在临床医学上是一个难题，因而受到了许多医学者的广泛研究[2-4]。在本文中，选取了在我院就诊的56例RNS病人，分为观察组（28例，采取CTX治疗）和对照组（28例，采取常规激素治疗），比较和分析2组病人在临床上的诊治效果和药物的不良症状。现研究结果如下。 　　1.资料与方法 　　1.1病例选择 　　在本研究中，抽取2012年3月到2015年3月在我院就诊的56例RNS患者，分为观察组和对照组。观察组男18例，女10例，年龄在18～79岁，平均年龄为43.6岁。对照组男17例，女11例，年龄在17～78岁，平均年龄为43.1岁。肾病病程在（12+ D_Dd__________