联合应用A型肉毒毒素与软组织填充剂治疗眉间纹临床观察.docVIP

联合应用A型肉毒毒素与软组织填充剂治疗眉间纹临床观察 　　[摘要]目的：探讨联合应用A型肉毒毒素与软组织填充剂治疗眉间纹的临床疗效。方法：研究对象为2012年7月～2013年7月我院接受治疗的68例眉间纹患者，其中26例行软组织填充治疗（设为对照组），42例联合应用A型肉毒毒素与软组织填充剂治疗（设为治疗组），统计疗效、患者满意率及并发症发生率。结果：治疗组的疗效及患者满意率均显著高于对照组，两组差异具有统计学意义（χ2=18.114、10.056，P0.05）。两组均未出现严重不良反应。结论：联合应用A型肉毒毒素与软组织填充剂治疗眉间纹疗效佳，并发症发生率低，值得推广应用。 　　[关键词]A型肉毒毒素；软组织填充剂；联合应用；眉间纹 　　[中图分类号]R622 [文献标识码]A [文章编号]1008-6455（2014）17-1418-03 　　Clinical observation of the treatment of glabellar lines by combined application of hyaluronic acid filling and botulinum toxintype A injection 　　LI Chuan-rong 　　（Department of Surgery Outpatient in Yichang city of Hubei Province， Yichang 443000， Hubei，China） 　　Abstract：Objective To investigate the clinical effect of the treatment of glabellar lines by combined application of hyaluronic acid filling and botulinum toxintype A injection. Methods The clinical data of 68 patients with glabellar lines n in our hospital from July 2012 to July 2013 were retrospectively analyzed，of whom 26 patients were given hyaluronic acid filling （control group）， and another 42 patients were given hyaluronic acid filling and botulinum toxintype A injection （treatment group），the curative effect，patient satisfaction and complication rate of two groups were observed and compared. Results In treatment group，the curative effect and patient satisfaction was significantly higher than that in control group（χ2=18.114、10.056，P0.05）.No serious adverse reactions were observed in the study.Conclusion Combined application of hyaluronic acid filling and botulinum toxintype A injection for the treatment of glabellar lines is safe and effect. It is worth spreading in clinic. 　　Key words： clinical effect；glabellar lines；combined application；hyaluronic acid filling；botulinum toxintype A injection 　　眉间纹是面部皱纹中一种常见的表情纹[1]，位于两眉之间，多为2～3条，主要为垂直走向，但下部纹常向两侧略呈八字形展开，与眉间肌纤维方向垂直，其由4块肌肉协同作用而产生，它们是皱眉肌、降眉肌、眼轮匝肌内上部肌纤维和额肌的下侧缘。随着年龄的增长，眉间纹会逐渐加深，因此，很多求美者会选择注射美容来去除这种表情纹。近年来，随着软组织填充术的不断发展，可供选择的填充材料也越来越多，新型填充材料，透明质酸凝胶实际上是一种透明质酸的衍生物[2-4]。采用A型肉毒毒素进行