联合检测血清胃蛋白酶原和抗 Hp IgG 抗体在消化溃疡诊断中价值探讨.docVIP

联合检测血清胃蛋白酶原和抗 Hp IgG 抗体在消化溃疡诊断中价值探讨 　　[摘要] 目的 探讨联合检测血清胃蛋白酶原和抗 Hp IgG 抗体在消化溃疡诊断中的价值。方法 方便选取2010年4月―2015年8月在该院消化科就诊的消化性溃疡患者150例，纳入病例组，另外选择同期在该院门诊行健康体检者100各作为健康对照组。对比两组对象血清PGⅠ、PGⅡ、PGⅠ/PGⅡ比值及Hp阳性情况。比较消化溃疡患者中Hp阳性者与阴性者的血清PGⅠ、PGⅡ及PGⅠ/PGⅡ比值情况。结果 病例组血清PGⅠ、PGⅡ水平及PGⅠ/PGⅡ值分别为（181.36±20.72）ng/mL、（24.81±9.65）ng/mL、（7.62±1.15）ng/mL，对照组分别为（53.67±19.64）ng/mL、（13.97±6.83）ng/mL、（4.57±1.46）ng/mL， 病例组血清PGⅠ、PGⅡ水平及PGⅠ/PGⅡ值明显高于对照组差异有统计学意义（P0.05）。病例组、对照组Hp阳性率分别为77.33%、24.00%，病例组Hp阳性率明显高于对照组（P0.05）。Hp阳性患者血清PGⅠ、PGⅡ水平及PGⅠ/PGⅡ值分别为（217.82±29.47）ng/mL、（ 28.53±10.81）ng/mL、（8.91±1.20），Hp阴性患者分别为（68.35±20.54）ng/mL、（17.02±7.15）ng/mL、（5.76±1.38）ng/mL， Hp阳性患者血清PGⅠ、PGⅡ水平及PGⅠ/PGⅡ值明显高于阴性患者差异有统计学意义（P0.05）。 结论 检测血清PG及Hp IgG抗体能对消化溃疡进行早期筛查，当两者出现异常时再行胃镜检查以明确诊断，从而一定程度提高了体检患者的检查依从性。 　　[关键词] 胃蛋白酶原；抗 Hp IgG 抗体；消化溃疡 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）06（c）-0020-04 　　[Abstract] Objective To explore the value of combined detectiing serum pepsinogen and anti Hp IgG antibody in diagnosis of peptic ulcer. Methods 150 peptic ulcer patients were collected in Gastroenterology department of our hospital from April 2010 to August 2015 and were included into patentes group， and 100 persons who were done health examination at the same period were included into healthy control group. The ratio of serum PG Ⅰ， PG Ⅱ， PG I/PGⅡ and Hp positive situation were compared between the two groups. The serum PG Ⅰ and PG Ⅱ and PG Ⅰ/PGⅡ ratio were compared between Hp positive patients and negative patients. Results The PG Ⅰ， PG II levels and PG Ⅰ/PG Ⅱ in patientes group were respectively （181.36±20.72） ng/mL、（24.81±9.65）ng/mL、（7.62±1.15）ng/mL，those in control group were respectively（53.67±19.64） ng/mL、（13.97±6.83）ng/mL、（4.57±1.46）ng/mL，the PG Ⅰ， PG II levels and PG Ⅰ/PG Ⅱ in patientes group were significantly higher than those in control group （P 　　[Key words] Pepsinogen； Anti Hp IgG antibody； Peptic ulcer 　　随着人们生活节奏的加快、工作压力增加，消化性溃疡患病率逐年升高。幽门螺杆菌（Hp）感染与消化溃疡间有密切的关系；胃蛋白酶原（PG）是一种胃蛋白酶前体，来源于消化道黏膜细胞，其血清浓度的改变能反映消化道黏膜的病变程度和功能变化。Hp、PG是目