联合检测宫颈阴道分泌物FFN和IL8预测早产价值.docVIP

联合检测宫颈阴道分泌物FFN和IL8预测早产价值 　　[摘要]目的了解先兆早产孕妇和正常妊娠孕妇的宫颈阴道分泌物中的胎儿纤维连接蛋白(FFN)、白细胞介素8(IL-8)的水平,观察联合检测FFN、IL-8是否提高预测早产的准确性。方法 使用ELISA法测定35例妊娠28~36周并诊断为先兆早产的孕妇(研究组)和51例同期同孕龄的正常孕妇(对照组)的宫颈阴道分泌物FFN和IL-8。结果(1)研究组的FFN和IL-8的含量高于对照组(P0.05),妊娠结局为早产组的FFN和IL-8的含量高于足月产组(P0.05)。FFN和IL-8呈正相关性(r=0.598,P0.05)。 结论(1)FFN和IL-8的浓度与早产相关,FFN和IL-8有正相关性。(2)联合检测宫颈阴道分泌物FFN和IL-8可以作为判断先兆早产预后的参考指标,FFN和IL-8 参与了先兆早产的发生发展。 　　[关键词]宫颈阴道分泌物FFN; IL-8; 早产 　　[中图分类号]R714.21[文献标识码]B [文章编号] 1005-0515(2010)-7-026-01 　　[Abstract]ObjectiveTo evaluate the significance of detecting FFN and IL-8 in cervicovaginal secretions of women with threatened preterm labor in predicting preterm delivery。MethodsSamples of cervicovaginal secretion were obtained from 35 patients with the diagnosis of threatened preterm labor (study group) and 51 pregnant women between the same gestational weeks(control group),and FFN and IL-8 were measured by ELISA. Results(1) FFN and IL-8 levels in study group were higher than those in control group(P0?05),which in the patients with preterm parturition were higher than those in the cases with term parturition(P0?05)?FFN level was positively correlated with IL-8 level(r=0?598,P0?05). Conclusions(1) FFN and IL-8 concentrations had relationships with preterm delivery,and FFN level was positively correlated with IL-8 level.(2) Significance of combined detection of cervicovaginal fetal fibronectin and interleukin-8 can be used as markers in predicting preterm delivery. Serum FFN and IL-8 perhaps play a role in the initiation and development ofthreatened in predicting preterm delivery. 　　[Keywords]Cervicovaginal fetal fibronectin;Interleukin-8; Preterm deliver 　　 　　早产是围产儿死亡和疾病的首要原因,产前保健重要任务之一即是如何预测和早期诊断早产,减少早产及相应并发症的发生。对早产的预测和预防已成为围生医学的重要课题[1]。本研究着重了解先兆早产孕妇和正常妊娠孕妇的宫颈阴道分泌物中胎儿纤维连接蛋白(FFN)和白细胞介素8(IL-8)的浓度变化及其与妊娠结局的相关性,两者之间的关系,观察联合检测FFN、IL-8是否提高预测早产的准确性,探讨新的预测早产的方法。 　　1 资料与方法 　　1.1 临床资料 　　选自深圳市宝安区龙华医院2007年12月～2010年3月诊断为先兆早产入院治疗的35例孕 　　妇作为研究组,同期同孕龄的正常孕妇51例作为对照组,研究组的入选对象为孕28～36周, 　　宫缩存在1h以上,宫缩30 s/7