联合检测甲胎蛋白α―岩藻糖苷酶β2―微球蛋白及透明质酸对诊断原发性肝癌意义.docVIP

联合检测甲胎蛋白α―岩藻糖苷酶β2―微球蛋白及透明质酸对诊断原发性肝癌意义 　　[摘要] 目的 探讨联合检测甲胎蛋白（AFP）、α-岩藻糖苷酶（AFU）、β2-微球蛋白（β2-m）及透明质酸（HA）对诊断原发性肝癌的意义。 方法 选取2012年3月～ 2014年3月在我院治疗的原发性肝癌患者60例、其他消化系癌症患者50例、肝硬化患者50例及正常健康人60例，检测所有患者血清AFP、AFU、β2-m及HA水平。 结果 原发性肝癌组患者血清AFU、AFP、β2-m、HA水平及阳性检出率明显高于其他消化系癌症组、肝硬化组及正常对照组，差异有统计学意义（P0.05）。原发性肝癌组患者血清AFU、AFP、β2-m、HA四项联合检测的敏感性、诊断符合率均优于单项检测，差异有统计学意义（P0.05）。 结论 联合检测AFU、AFP、β2-m、HA四种肿瘤标志物能提高早期原发性肝癌的敏感性和诊断率，为临床早期诊治提供可靠参考。 　　[关键词] 原发性肝癌；甲胎蛋白??α-岩藻糖苷酶；β2-微球蛋白；透明质酸 　　[中图分类号] R735.7 [文献标识码] B [文章编号] 2095-0616（2015）14-162-03 　　Significance of combined detection of alpha fetoprotein， alpha fucosidase， beta 2-microglobulin and hyaluronic acid in the diagnosis of primary liver cancer 　　YE Hong 　　Huiyang District Hospital of Traditional Chinese Medicine in Huizhou City， Huizhou 516211， China 　　[Abstract] Objective To investigate the significance of combined detection of alpha fetoprotein （AFP）， alpha fucosidase （AFU）， beta 2-microglobulin （β2-m） and hyaluronic acid （HA） in the diagnosis of primary liver cancer. Methods 60 patients with primary liver cancer， 50 cases of other digestive system cancer， 50 patients with hepatic cirrhosis and 60 normal people from 2012 March to 2014 March in our hospital were selected，and serum AFP， AFU， β2-m and HA levels of all patients were detected. Results The levels and positive rates of serum AFP， AFU， β2-m and HA of patients with primary liver cancer were significantly higher than those of patients with other digestive system cancer， liver cirrhosis and normal people， the difference was statiscally significant （P0.05）. The sensitivity and diagnostic accordance rate of combined detection of serum AFU， AFU， β2-m and HA in patients with primary liver cancer were better than those of the single detection， the difference was statiscally significant （P0.05）. Conclusion Combined detection of AFP， AFU， β2-m and HA four tumor markers can improve the sensitivity and diagnosis rate of early primary liver cancer， and provide the reliable reference for ear