联合检测CEACA199CA724对胃癌淋巴结转移及临床分期诊断价值.docVIP

联合检测CEACA199CA724对胃癌淋巴结转移及临床分期诊断价值 　　[摘要] 目的 通过对胃癌患者外周血癌胚抗原（CEA）、糖链抗原19-9（CA19-9），糖链抗原72-4（CA72-4）的单项检测和联合检测，探讨三种肿瘤标志物（TM）在胃癌淋巴结转移及分期中的敏感度。 方法 应用Elecsys 2010电化学发光全自动免疫分析系统检测63例胃癌患者外周血CEA、CA19-9、CA72-4水平。 结果 淋巴结转移组的血清CEA、CA19-9、CA72-4阳性率高于无淋巴结转移组，差异有统计学意义（P0.05），其余各组间Ⅰ期+Ⅱ期与Ⅲ期+Ⅳ期相比，差异有统计学意义（P0.05）。TNM分期中CEA+CA19-9+CA72-4联合检测阳性率均高于单项检测，差异有统计学意义（P0.05）。 结论 外周血CEA、CA19-9和CA72-4的联合检测可提高胃癌的检出率，淋巴结转移组阳性率明显增高，胃癌TNM分期的TM联合检测最佳组合为CEA+CA19-9+CA72-4。 　　[关键词] 肿瘤标志物；癌胚抗原；糖链抗原19-9；糖链抗原72-4；胃癌 　　[中图分类号] R735.2[文献标识码] A[文章编号] 1674-4721（2014）06（b）-0031-04 　　 　　The diagnostic value of combined detection of CEA,CA19-9 and CA72-4 on gastric cancer lymph node metastasis and clinical staging 　　MA Zhen-hua 　　Department of Gastroenterology,the First Affiliated Hospital of Baotou Medical College,Baotou 510700,China 　　[Abstract] Objective To discuss the sensitivity of three tumor markers(TM)in lymph node metastasis and clinical staging of gastric cancer by detecting carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 72-4(CA72-4)in the peripheral blood of patients. Methods CEA,CA19-9,CA72-4 of the peripheral blood in 63 cases of gastric cancer were detected by Elecsys 2010 electrochemiluminescence automatic immune analytic system. Results Positive rate of CEA,CA19-9,CA72-4 in lymph node metastasis group was higher than that in without lymph node metastasis group respectively,with statistical difference(P0.05),there was statistical difference between the Ⅰ+Ⅱ stage and Ⅲ+Ⅳ stage in other groups respectively(P0.05).Positive rate in combined detection was higher than that in single detection of CEA,CA19-9,CA72-4 respectively,with statistical difference(P0.05). Conclusion The combined detection of CEA,CA19-9 and CA72-4 in peripheral blood may improve the detecting rate of gastric cancer,lymph node metastasis group of gastric cancer is higher.The combined detection of CEA+CA19-9+CA72-4 is the best combination. 　　[Key words] Tumor marker;Carcinoembryonic ant