联合检测肿瘤抗原199肿瘤抗原242及D―二聚体对胰腺癌早期诊断意义.docVIP

联合检测肿瘤抗原199肿瘤抗原242及D―二聚体对胰腺癌早期诊断意义 　　[摘要] 目的 探讨肿瘤抗原199（CA199）、肿瘤抗原242（CA242）、D-二聚体联合检测在胰腺癌诊断中的临床意义。 方法 选取本溪市中心医院2009年1月～2014年12月收治的胰腺癌患者58例和2014年2～6月于体检中心体检健康成人60例分别作为胰腺癌组和对照组，两组分别采用电化学发光法进行血清CA199、CA242检测，免疫比浊法进行血浆D-二聚体检测，并比较两组试验检测结果。 结果 胰腺癌组血清CA199[（229.5±121.2）kU/L]、CA242[（60.2±23.9）kU/L]、血浆D-二聚体[（2.95±1.42）mg/L]水平，与对照组血清CA199[（19.2±9.2）kU/L]、CA242[（10.9±6.5）kU/L]、血浆D-二聚体[（0.45±0.22）mg/L]比较，检测值均明显升高，差异有统计学意义（t=3.452、3.024、3.592；P=0.002、0.002、0.001）。三项联合检测（CA199+CA242+D-二聚体）的敏感度和特异度分别为95.4%和96.9%，高于任意两项联合检测及单一项检测的敏感度和特异度，差异有统计学意义（P 0.05）。 结论 肿瘤抗原CA199、CA242及D-二聚体联合检测可提高胰腺癌诊断的敏感度和特异度，为临床诊断提供更为早期和准确的依据。 　　[关键词] 胰腺癌；糖类抗原；肿瘤相关；D-二聚体 　　[中图分类号] R735.04 [文献标识码] A [文章编号] 1673-7210（2015）07（a）-0136-04 　　[Abstract] Objective To discuss the value of combined detection of tumor markers CA199， CA242 and D-dimer levels in diagnosis of patients with pancreatic cancer. Methods 58 patients with pancreatic cancer （pancreatic cancer group） in Benxi Center Hospital from January 2009 to December 2014 and 60 healthy volunteers （control group） from February to June 2014 were selected. The serum levels of CA199 and CA242 were detected by electrochemiluminescence and the plasma level of D-dimer was detected by immunoturbidimetry. The detection results were compared. Results The levels of CA199 [（229.5±121.2） kU/L]， CA242 [（60.2±23.9） kU/L] and D-dimer [（2.95±1.42） mg/L] in the pancreatic cancer group were significantly higher than those of control group [（19.2±9.2） kU/L， （10.9±6.5） kU/L， （0.45±0.22） mg/L； t=3.452， 3.024， 3.592； P=0.002， 0.002， 0.001]. The sensitivity （95.4%） and specificity （96.9%） of CA199+CA242+D-dimer were the highest in those of any single items determination and in combination （P 0.05）. Conclusion With combined determination of CA199， CA242 and D-dimer can enhance the diagnostic sensitivity and specificity of pancreatic cancer， which is clinically valuable for early diagnostic of pancreatic cancer. 　　[Key words] Pancreatic cancer； Carbohydrate antigen； Tumor r