肝动脉化疗栓塞术联合射频消融术治疗肝细胞癌患者临床疗效观察.docVIP

肝动脉化疗栓塞术联合射频消融术治疗肝细胞癌患者临床疗效观察 　　【摘要】 目的 观察肝动脉化疗栓塞术（TACE）联合射频消融术（RFA）治疗肝细胞癌（HCC）患者的临床疗效。方法 62例HCC患者， 按照随机数字表法分为对照组和联合组， 各31例。对照组给予单纯的TACE治疗， 联合组在对照组基础上联合RFA治疗。观察比较两组患者的治疗效果、不良反应发生情况以及1、2年内的病死情况。结果 联合组有效率为90.32%（28/31）， 高于对照组的67.74%（21/31）， 差异具有统计学意义（P0.05）。联合组不良反应发生率为67.74%（21/31）， 低于对照组的90.32%（28/31）， 差异具有统计学意义（P0.05）。1年内， 联合组病死率为25.81%（8/31）， 低于对照组的51.61%（16/31）， 差异具有统计学意义（P0.05）。2年内， 联合组病死率为35.48%（11/31）， 低于对照组的61.29%（19/31）， 差异具有统计学意义（P0.05）。结论 对HCC患者使用TACE联合RFA的治疗方法， 可明显提高临床效果， 且能有效改善预后， 降低不良反应发生率和2年内的病死率。 　　【关键词】 肝细胞癌；肝动脉化疗栓塞术；射频消融术 　　DOI：10.14163/j.cnki.11-5547/r.2018.06.013 　　【Abstract】 Objective To observe the clinical efficacy of transcatheter arterial chemoembolization （TACE） combined with radiofrequency ablation （RFA） in the treatment of hepatocellular carcinoma （HCC）. Methods A total of 62 HCC patients were divided by random number table method into control group and combination group， with 31 cases in each group. The control group was treated with TACE only， and the combination group was treated with RFA on the basis of the control group. Observation and comparison were made on treatment effect， occurrence of adverse reactions and death condition in 1 and 2 years between the two groups. Results The combination group had higher effective rate as 90.32% （28/31） than 67.74% （21/31） in the control group， and the difference was statistically significant （P0.05）. The combination group had lower incidence of adverse reactions as 67.74% （21/31） than 90.32% （28/31） in the control group， and the difference was statistically significant （P0.05）. Within 1 year， the combination group had lower death rate as 25.81% （8/31） than 51.61% （16/31） in the control group， and the difference was statistically significant （P0.05）. Within 2 years， the combination group had lower death rate as 35.48% （11/31） than 61.29% （19/31） in the control group， and the difference was statistically significant （P0.05）. Conclusion Combination of TACE and RFA can obviously improve clinical