联合检测BNP和cTnI在急性心肌梗死中临床意义.docVIP

联合检测BNP和cTnI在急性心肌梗死中临床意义 　　【摘要】目的 探讨联合检测血浆脑钠肽（BNP）和血清心肌钙蛋白（cTnI）在急性心肌梗死患者中的临床意义。方法 选取50例我院的心肌梗死患者作为观察组，50名健康体检者作为对照组，①采用化学免疫荧光法定量测定BNP，乳胶增强免疫比浊法测定cTnI水平，其中观察组分别检测胸痛后2 h、6 h、12 h三个时间点的BNP和cTnI值；②比较分析单个测定和联合测定对诊断AMI的敏感性和特异性。结果 观察组血清BNP和cTnI水平明显高于对照组，且随时间延长明显升高，差异有统计学意义（P0.05）；BNP和cTnI随着时间延长其敏感度和特异度都变得更优，但两项联合检测敏感度和特异度明显优于单独检测（P0.05）。结论 联合检测BNP和cTnI是诊断急性心肌梗死的敏感指标，能很好的预测发生AMI的危险性，有较高的临床价值。 　　【关键词】血浆脑钠肽；血清心肌钙蛋白；急性心肌梗死 　　【中图分类号】R542.2 【文献标识码】B 【文章编号】ISSN.2095-6681.2015.07.00.02 　　Clinical Application of Combined Determination of BNP and 　　cTnI for Diagnosis and Outcome Prediction in Patients 　　with Acute Myocardial Infarction 　　WANG Dong 　　（Inner Mongolia Bayannaoer City Wuyuan county Peoples Hospital，Inner Mongolia Bayannaoer 015100，China） 　　【Abstract】Objective To investigate the significance of combined determination of plasma brain natriuretic peptide（BNP）and serum cardic troponin I（cTnI）for diagnosis and outcome prediction in patients with AMI. Methods Selected 50 cases of our hospital patients with myocardial infarction as observation group，50 cases of healthy physical examination as control group.①BNP were detected by using fluorescence immunoassay，cTn1 were detected by using latex immunoturbidimetry，observation group patients were measured this value of BNP and cTnI at2，6，12 hours after chest pains.②The respective sensitivity，specificity and their relativity were analyzed. Results Compared with control group，there was a significant increase in BNP and cTnI of observation group ，and significant increase with the time extended （P0.05）.The respective sensitivity and specificity were better with the time extended. combined detection BNP and cTnl was better than detection alone（P0.05）. Conclusion The measurement of BNP and cTnI in combination is a less sensitive index of AMI.It is helpful to the early diagnosis of AMI. 　　【Key words】Brain natriuretic peptide；Cardiac Troponin I；Acute myocardial infarction 　　急性心肌梗死（AMI）是老年人常见的急危险疾病之一，其发病率在我国呈上升趋势[1]，发病急，进展快，正确诊