联合检测RDWhs―CRP及IMA对CHD应用价值.docVIP

联合检测RDWhs―CRP及IMA对CHD应用价值 　　[摘要] 目的 探讨RDW、hs-CRP及IMA的联合检测在冠状动脉粥样硬化性心脏病（CHD）诊断中的应用价值。 方法 分别用Sysmex 2000i，免疫比浊法和清蛋白钴结合试验测定待检对象血清中RDW、hs-CRP及IMA含量。 结果 实验组血清标本中RDW、hs-CRP和IMA的浓度明显高于对照组（P0.01）。实验组血清RDW、hs-CRP和IMA单项检测，阳性检出率分别为52.7%，65.5%，59.0%，3项联合检测阳性检出率达82.5%。联合检测阳性检出率与单项检测阳性检出率比较差异有统计学意义（P0.05）。 结论 血清RDW、hs-CRP及IMA联合检测可有助于提高CHD的阳性检出率，其浓度变化可为CHD疾病的临床诊断、治疗监测和预后提供一定的参考价值。 　　[关键词] 红细胞平均分布宽度；超敏C反应蛋白；冠心病；缺血修饰清蛋白 　　[中图分类号] R542.2 [文献标识码] B [文章编号] 2095-0616（2014）16-93-03 　　The application value of combining detection of RDW、hs-CRP and IMA in CHD 　　WANG Jian PENG Xinguo JI Bing QU Huiqing XIAO Lei 　　Affiliated Hospital of Binzhou Medical College，Binzhou 256600，China 　　[Abstract] Objective To investigate the application value of joint detection of RDW，Hs-CRP and IMA in CHD. Methods The serum levels of RDW 、hs-CRP and IMA were measured respectively by Sysmex 2000i ，immunoturbidimetry and Albumin cobalt binding test compared with the control group. Results The serum levels of RDW、hs-CRP and IMA in experimental group were significantly higher than those in control group（P0.01）.The positive rate were respectively 52.7%，65.5%，59.0%.In experimental group using single detection of RDW、hs-CRP and IMA.The positive rate was 82.5% through combined detection of RDW、hs-CRP and IMA. .The differences were statistically significant（P0.05）. Conclusion The combined detection of serum RDW， Hs-CRP and IMA may be profitable to the diagnose of CHD and serum RDW、Hs-CRP and IMA levels were of great value in clinical diagnosis、treatment monitoring and prognosis of CHD. 　　[Key words] The average red blood cell distribution width； High-sensitivity C-reactive protein； Coronary heart disease； Ischemia modified albumin 　　冠心病（coronary artery heart disease，CHD）是由于脂类代谢异常，一些类似粥样脂类物质堆积在动脉内膜，造成管腔狭窄，血流受阻，心肌供血不足，发生心绞痛，严重者可导致心力衰竭而死亡。临床表现复杂，缺乏特异性体征，易被漏诊误诊，缺乏在早期诊断和比较特异性诊断指标。RDW、hs-CRP及IMA单项检测对CHD疾病的评估诊断效果较低，本研究通过联合检测RDW、hs-CRP及IMA来探讨其在CHD疾病的评估诊断效果。 　　1 材料与方法 　　1.1 一般资料 　　选择2013年1～12月期间住院患者110例，男75例，女35例，年龄