肝动脉栓塞化疗联合槐耳颗粒对不可切除结直肠癌肝转移预后影响.docVIP

肝动脉栓塞化疗联合槐耳颗粒对不可切除结直肠癌肝转移预后影响 　　[摘要] 目的 探讨肝动脉栓塞化疗（transarterial chemoembolization， TACE）联合槐耳颗粒对不可切除结直肠癌肝转移患者长期生存的影响。方法 回顾性分析2010年6月～2014年6月间在我院就诊的75例结直肠癌肝转移患者的临床资料。其中联合组36例患者接受肝动脉栓塞化疗同时口服槐耳颗粒（20 g/次，3次/d），并在肝动脉栓塞化疗结束后继续维持服用，对照组39例患者仅接受肝动脉栓塞治疗。观察两组患者并发症及长期生存情况。 结果 联合组3年无肝内复发生存率明显高于对照组（12/36 vs.10/39，χ2=4.4426，P=0.0351， HR=0.5748， 95%CI： 0.3325～0.9936）；联合组3年总存活率明显高于对照组（18/36 vs 13/39， χ2=4.5397，P=0.0331， HR=0.5343，95%CI：0.2944～0.9696）。结论 肝动脉栓塞化疗同时联合使用槐耳颗粒能明显减少肝内复发，从而改善不可切除结直肠癌肝转移患者的长期生存。 　　[关键词] 肝转移；经肝动脉化疗栓塞术；预后；总生存率；肝内复发 　　[中图分类号] R735.34 [文献标识码] A [文章编号] 1673-9701（2017）31-0021-04 　　[Abstract] Objective To investigate the effect of transarterial chemoembolization （TACE） combined with Huaier granules on long-term survival of patients with liver metastasis of non-resectable colorectal cancer. Methods The data of 75 patients with liver metastasis of colorectal cancer who were admitted to our hospital from June 2010 to June 2014 were retrospectively analyzed. Among them， 36 patients in the combined group were given TACE combined with oral administration of Huaier granules（20 g/time， 3 times/day）， and the patients were continuously administered after the end of TACE. In the control group， 39 patients were only given TACE. The complications and long-term survival of the two groups were observed. Results The 3-year liver recurrence-free survival rate in the combined group was significantly higher than that in the control group（12/36 vs. 10/39， χ2=4.4426， P=0.0351， HR=0.5748， 95%CI：0.3325-0.9936）； the 3-year total survival rate in the combined group was significantly higher than that in the control group （18/36 vs. 13/39， χ2=4.5397， P=0.0331， HR=0.5343， 95%CI：0.2944-0.9696）. Conclusion Hepatic arterial chemoembolization combined with Huaier granules can significantly reduce intrahepatic recurrence， so as to improve the long-term survival of patients with liver metastasis of unresectable colorectal cancer. 　　[Key words] Liver metastasis； Transarterial chemoembolization