血清白介素6与胱抑素C联合检测对糖尿病肾脏疾病早期诊断价值.docVIP

血清白介素6与胱抑素C联合检测对糖尿病肾脏疾病早期诊断价值 　　 　　[摘要] 目的 分析血清白介素6（IL-6）与胱抑素C（CysC）联合检测对糖尿病肾脏疾病（DKD）早期的诊断价值。方法 选取常德职业技术学院附属第一医院肾内科2012年6月～2013年6月收治的110例糖尿病（DM）患者，其中65例患者尿白蛋白排泄率（UAER）＜20 μg/min设置为无早期肾损伤组，即DM组，其余45例糖尿病患者UAER 20～200 μg/min设置为糖尿病肾脏疾病组，即DKD组，统计分析两组患者CysC、IL-6水平。 结果 DKD组患者CysC、IL-6、CRP水平显著高于DM组（P ＜ 0.05）。DKD组患者CysC、IL-6单项检测阳性率为60.0%、75.6%，双项阳性率为84.4%，而DM组阳性率分别为27.7%、36.9%、44.6%，两者差异有统计学意义（P ＜ 0.05），两组患者CysC、IL-6单项检测阳性率显著低于CysC、IL-6双项检测阳性率（P ＜ 0.05）。 结论 IL-6与CysC联合检测可有效提高糖尿病肾脏疾病检测阳性率，是早期糖尿病肾脏疾病确诊的重要方法之一。 　　[关键词] 血清白介素6；胱抑素C；糖尿病肾脏疾病 　　[中图分类号] R587.2[文献标识码] A[文章编号] 1673-7210（2014）05（a）-0078-03 　　 　　Serum interleukin-6 and cystitis C combined detection in diagnosis of early diabetic kidney disease 　　LIU Guoyong1 HE Liyu2 SHI Yan1 YI Fayun1 XIAO Guoqiu1 YANG Qing1 SHE Jian1 XU Haiqin1 LONG Qing1 　　1.Department of Internal Medicine, the First Affiliated Hospital of Career Technical College in Changde City, Hu′nan Province, Changde 415000, China; 2.Research Institute of Nephrology, Xiangya Second Hospital of Central South University in Changsha, Hu′nan Province, Changsha 410016, China 　　[Abstract] Objective To analyze the early diagnostic value of the serum interleukin 6 (IL 6) and joint detection (inhibition C (CysC) on diabetic kidney disease (DKD). Methods 110 cases of treated diabetes in Department of Internal Medicine of the First Affiliated Hospital of Career Technical College in Changde City were selected from June 2012 to June 2013, including 65 cases of urinary albumin excretion rate (UAER) 20 μg/min which was setted to no early renal injury group (DM group), and the remaining 45 cases diabetes UAER 20 - 200 μg/min which was setted for diabetic kidney disease group (DKD group), two groups of patients with the level of IL-6 and Cys C were statistically analyzed. Results DKD patients of CysC, IL-6, CRP levels were significantly higher than those in DM group (P 0.05). DKD patients for single test positive rate of CysC, IL-6 was 60.0%, 75.6%, double entry posi