辛伐他汀联合阿司匹林治疗脑血栓效果及对神经功能缺损影响.docVIP

辛伐他汀联合阿司匹林治疗脑血栓效果及对神经功能缺损影响 　　[摘要] 目的 探讨辛伐他丁汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响。 方法 选择2013年5月～2015年2月武警浙江总队嘉兴医院神经内科收治的118例脑血栓患者作为研究对象，按随机数字表法将其分为观察组和对照组，每组59例。根据入组患者的脑血栓症状给予相关常规治疗，此后对照组患者给予口服药物阿司匹林治疗，观察组患者给予药物阿司匹林+辛伐他汀治疗，疗程为6个月。随访半年，通过颈动脉超声检测比较两组患者治疗前后颈动脉内膜中层厚度（IMT）及颈动脉斑块面积的差异，采用酶法、肝素-MnCl2法分别测定两组患者治疗前后的三酰甘油（TG）、血清总胆固醇（TC）水平及高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平，并通过Barthel指数及美国国立卫生研究院卒中量表（NIHSS）评定两组患者治疗前后的日常生活能力和神经缺损功能。 结果 治疗后两组患者IMT及斑块面积均较治疗前显著降低（P 0.05）；治疗后两组患者NIHSS评分较治疗前显著降低（P 0.05），Barthel指数评分较治疗前显著升高（P 0.05），且观察组治疗后NIHSS评分明显低于同期对照组，Barthel指数评分明显高于同期对照组（P 0.05）。 结论 采用辛伐他汀联合阿司匹林治疗脑血栓患者临床效果显著，缩小了颈动脉斑块面积及厚度，降低了血脂，减轻了患者的神经功能缺损，提高了患者的日常生活能力，值得临床推广使用。 　　[关键词] 辛伐他汀；阿司匹林；脑血栓；颈动脉斑块 　　[中图分类号] R743 [文献标识码] A [文章编号] 1673-7210（2016）08（b）-0161-04 　　[Abstract] Objective To investigate the effect of Simvastatin combined with Aspirin in the treatment of cerebral thrombosis and its influence on neurologic impairment. Methods One hundred and eighteen cases of patients with cerebral thrombosis admitted to Department of Neurology of Jiaxing Hospital of Zhejiang Armed Police Corps from May 2013 to February 2015 were selected as research objects， and they were randomly divided into observation group and control group according to random number table method， with 59 cases in each group. The enrolled patients were given relevant conventional treatment according to the symptoms of cerebral thrombosis. Then the control group was given oral drug Aspirin， while the observation group was given Aspirin + Simvastatin， the course was 6 months. Followed-up for half a year， the carotid artery ultrasound was used to detect the changes of carotid intima media thickness （IMT） and carotid plaque area before and after treatment between the two groups， the enzymic method and heparin-MnCl2 method was respectively used to detect the levels of triacylglycerol （TG）， serum total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C）， low density lipoprotein cholesterin （LDL-C）， and Barthel index an