辛伐他汀联合曲美他嗪治疗慢性心力衰竭疗效观察.docVIP

辛伐他汀联合曲美他嗪治疗慢性心力衰竭疗效观察 　　[摘要]目的探讨辛伐他汀与曲美他嗪联合治疗慢性心力衰竭（CHF）的疗效。方法采用随机数字表法将76例CHF患者分为对照组和观察组，对照组（38例）给予抗心力衰竭常规治疗，治疗组（38例）在上述基础上加用辛伐他汀与曲美他嗪联合治疗，比较两组治疗前后心功能各指标改善情况以及血浆高敏C反应蛋白（hs_CRP）的变化情况。结果观察组的治疗总有效率明显高于对照组，差异有统计学意义（P0.05）；治疗后左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）以及左心室舒张末期内径（LVEDD）改善情况优于对照组，差异具有统计学意义（P0.05）；血浆hs_CRP水平下降程度较对照组明显，治疗后6min步行试验行走距离亦明显长于对照组，差异均有统计学意义（P0.05）。结论辛伐他汀与曲美他嗪联合治疗CHF，在抗炎的同时能够改善患者心功能，降低心肌耗氧，提高心力衰竭患者运动耐量。 　　[关键词]辛伐他汀；曲美他嗪；慢性心力衰竭；心功能 　　中图分类号：R541.6；R972文献标识码：A文章编号：1009_816X（2014）05_0369_03 　　doi：10.3969/j.issn.1009_816x.2014.05.05Effects of Simvastatin Combined with Trimetazidine on Cardiac Function in Patients with Chronic Heart Failure and High_sensitivity C_reactive Protein. CAI Wen_biao， QI Chun_mei， FENG Jian_qi， et al. Department of Cardiovascular， The Second Afflicted Hospital of Xuzhou Medical College， Jiangsu 221006， China 　　[Abstract] Objective To discuss the superiority of simvastatin combined with trimetazidine in treatment of chronic heart failure （CHF）. Methods Using the methods of random number table， 76 patients with CHF were divided into the control group and the observation group， with 38 cases in each group. The control group was given conventional treatment of heart failure_resistant while the observation group was treated with additional combined simvastatin and trimetazidine. Then the cardiac function indexes， cardiac function grading and plasma high_sensitivity c_reactive protein （HS_CRP） were compared before and after treatment in both groups. Results The treatment effect of cardiac function in observation group was significantly higher than that in the control group （86.8% vs 71%， P0.05）； LVEF， LVESD and LVEDD in observation group （52.3±5.1， 47.2±6.9， 57.3±7.1） improved better than the control group （41.9±4.8， 52.6±7.1， 63.3±7.5） （P0.05）. Besides， the plasma hs_CRP in observation group decreased significantly compared with the control group （P0.05）. After treatment， the patients in observation group can walk great further than the