辛伐他汀对老年2型糖尿病血脂超敏C反应蛋白影响.docVIP

辛伐他汀对老年2型糖尿病血脂超敏C反应蛋白影响 　　[摘要] 目的：探讨常规剂量、短疗程辛伐他汀对老年2型糖尿病（T2DM）患者血脂、C反应蛋白（CRP）的影响。方法：60例LDL-C≥2.6 mmol/L的老年T2DM患者随机分为两组：辛伐他汀组采用辛伐他汀20 mg/d＋常规治疗，对照组采用常规治疗，于治疗前及治疗后2周分别测定血脂、超敏C反应蛋白（hsC-RP）等指标。结果：辛伐他汀组治疗2周后 TC、TG、LDL-C、hsC-RP较治疗前显著下降，差异具有统计学意义（P＜0.05），且hsC-RP下降与TC、TG、LDL-C下降无相关性；对照组上述指标较治疗前虽有下降，但差异无统计学意义。所有受试者均未发现血清转氨酶（ALT）、肌酸激酶（CK）升高及肾功能损害。结论：常规剂量、短疗程辛伐他汀可显著降低老年T2DM患者LDL-C水平，而且具有独立于降脂作用之外的显著降低hsC-RP水平的作用，从而具有防治老年T2DM患者动脉粥样硬化的发生、发展的作用，且安全性良好。 　　[关键词] 辛伐他汀；2型糖尿病；血脂；超敏C反应蛋白；动脉粥样硬化 　　[中图分类号] R587[文献标识码]B [文章编号]1673-7210（2008）01（b）-018-03 　　 　　The effection of simvastatin to serum lipide,high sensitivity C-reactive protein in elderly type 2diabetic patients 　　ZHANG Xiu-bin1, KUANG Jin-song1, XIN Yue-ying1,WANG Qiu-yue2 　　（1.Department of Endocrinology,the Fourth Peoples Hospital of Shenyang, Shenyang 110031, China;2.Department of Endocrinology,the First Affiliated Hospital,China Medical Vniversity,Shenyang 110001,China） 　　[Abstract] Objective: To research the effect of simvastatin to serum lipid,high sensitivity C-reactive protein (hsC-RP) and safety in elderly type 2 diabetic patients.Methods: Sixty type 2 diabetic patients,aged ＞60,and LDL-C ≥2.6 mmol/L,were randomly divided into two groups. 30 patients were involved as simvastatin group treated with simvastatin 20 mg/d and conventional therapy for 2 weeks. Others only treated by conventional therapy as control were convention group.Serum levels of TC、TG、LDL-C、hsC-RP were measured before and after treatment.Results:After 2 weeks,the levels of TC、TG、LDL-C、hsC-RP reduced significantly in the simvastatin group than those of before(P＜0.05).In addition,the decrease of hsC-RP was no relation with the decrease of TC、TG 、LDL-C . The levels of TC、TG、LDL-C、hsC-RP decreased after 2 weeks in the convention group, but no significant change were found comparing to the beginning of the study(P＞0.05).The levels of serum transaminase, creatine phosphokinase and creatinine in all tested patients kept normal although the study.Conc