2型糖尿病患者血清骨钙素和糖代谢相关性研究.docVIP

2型糖尿病患者血清骨钙素和糖代谢相关性研究 　　[摘要] 目的 探讨2型糖尿病患者血清骨钙素（OC）与糖代谢的相关性。方法 抽取2016年3月―2017年3月至该院就诊的糖尿病患者120例，依照性别进行分组，分析两组的相关指标。结果 男性组的血清OC水平和HOMA-IR、HbAlc、FBG为负相关，与HOMA-β为正相关（P0.05）；绝经前女性组的血清OC水平与HOMA-IR、HbA1c为负相关，与HOMA-β为正相关（P0.05）；进行多元逐步回归分析后得知两组患者的HbALC独立相关因子均为FBG、ALP、LDL-c、OC。结论 分析2型糖尿病患者的血清OC和糖代谢指标具有紧密的关联性，临床上可帮助患者对胰岛素抵抗进行改善，便于促进胰岛素的分泌，调节糖代谢现象。 　　[关键词] 血清骨钙素；糖代谢；2型糖尿病；相关性 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0026-03 　　Correlation between Serum Osteocalcin and Glucose Metabolism in Type 2 Diabetic Patients 　　YIN Cai-jun1， LI Hong-mei1， HU Jing2， WANG Wei1， ZHANG Gui-xiang1， YANG Yan-li1， JIN Quan-peng1， MA Feng-zhen1 　　1.Department of Endocrinology， Ningxia People’s Hospital， General Hospital， Yinchuan， Ningxia， 750000 China； 2.Department of Endocrinology， Ningxia People’s Hospital， Xixia Hospital， Yinchuan， Ningxia， 750000 China 　　[Abstract] Objective This paper tries to investigate the correlation between serum osteocalcin （OC） and glucose metabolism in patients with type 2 diabetes mellitus. Methods 120 patients with diabetes who admitted to the hospital from March 2016 to March 2017 were divided into two groups according to their gender. The related index of the two groups were compared. Results The serum OC level of the male group was negatively correlated with HOMA-IR， HbA1c， and FBG， which was positively correlated with HOMA-β （P0.05）. The serum OC levels of premenopausal women were negatively correlated with HOMA-IR and HbAlc， which were positively correlated with HOMA-β（P0.05）； After multiple stepwise regression analysis， the HbALC independent correlation factors of the two groups were FBG， ALP， ldl-c and OC. Conclusion Analysis of type 2 diabetes serum OC and glucose metabolism indicators are closely related， to clinically help patients to improve insulin resistance， facilitate the promotion of insulin secretion， regulating glucose metabolism. 　　[Key words] Serum osteocalcin； Glucose metabolism； Type 2 diabetes； Correlation 　　骨钙素属于一类直链多肽