乌司他丁和奥曲肽联合治疗轻症急性胰腺炎临床研究.docVIP

乌司他丁和奥曲肽联合治疗轻症急性胰腺炎临床研究 　　[摘要] 目的 探讨乌司他丁与奥曲肽联合治疗轻症急性胰腺炎的临床疗效。 方法 将入组的89例轻症急性胰腺炎患者随机分为观察组（45例）和对照组（44例）。两组患者均予以常规治疗，包括禁食；胃肠减压，对于腹痛、腹胀、呕吐严重者置胃管持续吸引胃肠减压；经脉输液，积极补充血容量，维持水电解质和酸碱平衡；予以哌替啶止痛；抗生素及抑制胃酸等。对照组在常规治疗基础上加用注射用醋酸奥曲肽；观察组在对照组治疗上应用乌司他丁。两组患者疗程均为5 d，评价疗效。 结果 观察组总有效率为91.11%，对照组总有效率为75.00%，两组总有效率比较差异有统计学意义（P ＜ 0.05）。观察组患者治疗后血清淀粉酶[（454±87）U/L]、尿淀粉酶[（592±231）U/L]变化与对照组[（520±103）、（766±250）U/L]比较差异均有高度统计学意义（均P ＜ 0.01）。 结论 乌司他丁与奥曲肽联合能够起到协同治疗作用，能显著改善急性轻症胰腺炎患者血清淀粉酶、尿淀粉酶水平，提高临床疗效，值得推广使用。 　　[关键词] 轻症急性胰腺炎；奥曲肽；乌司他丁；白细胞介素 　　[中图分类号] R576 [文献标识码] A [文章编号] 1673-7210（2012）01（b）-091-02 　　 　　Clinical research of combined Ulinastatin and Octreotide in the treatment of mild acute pancreatitis 　　HUANG Qicong 　　Department of Gastroenterology, the Peoples Hospital of Dapu County, Guangdong Province, Dapu 514200, China 　　[Abstract] Objective To explore the clinical efficacy of combined Ulinastatin and Octreotide in the treatment of mild acute pancreatitis. Methods 89 cases of patients with mild acute pancreatitis were randomly divided into experiment group (45 cases) and control group (44 cases). Both of the two groups were given basic treatment, including ambrosia; gastrointestinal decompression for patients with severe abdominal pain, abdominal distension and vomiting by installing stomach tube to obtain continuous drawing; venous transfusion to actively supply blood volume and maintain water-electrolyte balance and acid-base balance; relieving pain with pethidine; taking antibiotics; inhibiting gastric acid secretion, and so on. Octreotide acetate for injection was added to control group on the basis of basic treatment, and Ulinastatin was added to experiment group on the basis of control group. The course of treatment was 5 d in both groups, then the clinical efficacy was assessed. Results The total effective rate was 91.11% in experiment group and 75.00% in control group. The differences were significant (P ＜ 0.05). The level of serum amylase [(454±87)U/L] and urine amylase [(592±231