IP和EP方案治疗广泛期小细胞肺癌临床对比分析.docVIP

IP和EP方案治疗广泛期小细胞肺癌临床对比分析 　　[摘要] 目的 对比分析IP与EP方案治疗广泛期小细胞肺癌的临床效果。方法 整群选择2013年2月―2014年1月来该院治疗广泛期小细胞肺癌的患者80例，随机将其分两组，每组40例。IP组采用IP方案对患者进行化疗，EP组采用EP方案对患者进行化疗，观察两组患者化疗效果。结果 EP组治疗有效率为72.50%，IP组治疗有效率为80.00%，EP组与IP组治疗有效率差异无统计学意义（P0.05），IP组腹泻发生率为35.00%，EP组腹泻发生率为2.50%，IP组腹泻发生率明显高于EP组，差异有统计学意义（P0.01），两组患者均顺利进行化疗，未出现毒副反应。结论 采用EP方案治疗广泛期小细胞肺癌，能有效的减少腹泻率，但不降低治疗效果，相对而EP方案更可行。 　　[关键词] IP方案；EP方案；广泛期小细胞肺癌 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1674-0742（2016）01（b）-0120-02 　　Clinical Comparative Analysis of IP Plan and EP Plan in Treatment of Extensive Small-cell Lung Cancer 　　WANG Hong-li 　　Three ward， oncology department， The First Affiliated Hospital of Nanyang Medical College， Nanyang， Henan Province， 473000 China 　　[Abstract] Objective To comparatively analyze the clinical effect of IP plan and EP plan in treatment of extensive small-cell lung cancer. Methods 80 cases of patients with extensive small-cell lung cancer treated in our hospital from February 2013 to January 2014 were selected and randomly divided into two groups with 40 cases in each， the IP group were treated with chemotherapy by IP plan， the EP group were treated with chemotherapy by EP plan， the chemotherapy effects of the two groups were observed. Results The total treatment effective rate was 72.50% in EP group and 80.00% in IP group， and there was no obvious difference between the two groups （P0.05）； the incidence of diarrhea in IP group was obviously higher than that in EP group （35.00% vs 2.50%） and the difference was obvious （P0.01）， the two groups were treated with chemotherapy successfully and no adverse reactions occurred. Conclusion EP plan in treatment of f extensive small-cell lung cancer can effectively reduce the incidence of diarrhea but not reduce the treatment effect， and it is more feasible than EP plan. 　　[Key words] IP plan； EP plan； Extensive small-cell lung cancer 　　肺癌是临床常见疾病之一，其发病率高，死亡率高[1]。尤其近几年，随着环境质量不断下降，肺癌的发病率不断上升，已经成为威胁人类健康的首号杀手[2]。小细胞肺癌的发病率达到20%，其恶性程度高、倍增时短，转移早而广泛，并且极易复发[3]。目前临床一般采用化疗治