A Good Practice Guide to the Administration of substances and Removal of Blood外文.pdf

JOURNAL OF APPLIED TOXICOLOGY J. Appl. Toxicol. 21, 15–23 (2001) A Good Practice Guide to the Administration of Substances and Removal of Blood, Including Routes and Volumes 1 2 3 4 5 Karl-Heinz Diehl , Robin Hull , David Morton , Rudolf Pfister , Yvon Rabemampianina , David Smith6,*, Jean-Marc Vidal7 and Cor van de Vorstenbosch8 1Aventis, PO Box 1140, D35001 Marburg, Germany 2N I B S C, Blanch Lane, South Miimms, Potters Bar, Hertfordshire EN6 3QG 3The University of Birmingham, Medical School, Edgbaston, Birmingham B15 2TT 4Novartis Pharma AG, CH-4002 Basel, Switzerland 5 ´ Centre de Recherche Pfizer, Etablissement d’Amboise, Z1 Poce-sur-Cisse-BP 159 37401 Amboise Cedex, France 6AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH 7 ´ Aventis, 102 Route de Noisy, 95235 Romainville Cedex, France 8N V Organon, PO Box 20, 5340 BH Oss, Netherlands Key words: blood volumes; blood removal; administration substances; laboratory animals; refinement. This article is the result of an initiative between the European Federation of Pharmaceutical Industries Associations (EFPIA) and the European Centre for the Validation of Alternative Methods (ECVAM). Its objectives are to provide the researcher in the safety evaluation laboratory with an up-to-date, easy- to-use set of data sheets to aid