炎症标记物与缺血性中风预后评价.PDF

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 12 :897-904 ( ) 897 炎症标记物与缺血性中风预后评价 * ** 王艺璇，冉桂梅，严颐丹，江慧勇，何华 ，柳晓泉 （中国药科大学药物代谢动力学研究中心，江苏 南京 210009） [ 摘要 ] 缺血性中风触发的炎症反应是一个级联放大过程，不仅可直接对缺血脑组织造成继发性损伤，还可通过与其他病理生理通路的相互 影响、相互促进，共同对缺血后脑组织造成不可逆损伤。因此，采用炎症标记物对脑缺血损伤及其预后进行评价，具有重要临床意义。临 床研究发现，多炎症标记物法用于缺血性中风的诊治和预后评价比单炎症标记物法更全面、更准确，故更具明显优势。综述脑缺血引发的 炎症机制、脑缺血所致炎症通路与其他病理生理通路 ( 如氧化应激、细胞凋亡和兴奋性毒性 ) 的关联以及炎症标记物在缺血性中风预后评价 中的应用。 [ 关键词 ] 缺血性中风；炎症机制；炎症标记物；预后评价 [ 中图分类号 ] R743.31 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）12-0897-08 Inflammatory Markers and Prognosis Evaluation of Ischemic Stroke WANG Yixuan, RAN Guimei, YAN Yidan, JIANG Huiyong, HE Hua, LIU Xiaoquan ( Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Inflammatory cascade triggered by ischemic stroke can not only cause secondary ischemic brain damage directly, but also interact with other pathophysiological pathways, resulting in irreversible brain damage. Therefore the inflammatory markers used in the evaluation of cerebral ischemic injury and its prognosis have important clinical significance. In clinical studies it has been suggested that the assessment with multi- inflammatory markers can provide more sufficient and more accurate information on the diagnosis and prognosis of ischemic stroke than single- inflammatory marker, and thus has greater advantages. The inflammatory mechanism caused by cerebral ischemia, the association of the inflammatory pathway induced by cerebral ischemia with other pathophysiological pathways such as oxidative stress, apo